Social correlates of the dominance rank and long-term cortisol levels in adolescent and adult male rhesus macaques (Macaca mulatta)

	Social correlates of the dominance rank and long-term cortisol levels in adolescent and adult male rhesus macaques (Macaca mulatta)
	Feng XL1; Wu XJ 1,2; Morrill RJ 1; Li ZF 1,2; Li CL 1; Yang SC 1; Li ZX 1; Cui D 3,5; Lv LB 4; Hu ZF 4; Zhang B 1; Yin Y 7; Guo LY 8; Qin DD1,3,5; Hu XT*1,6; virgo1985712@163.com ; qindong108@163.com ; xthu@mail.kiz.ac.cn
	2016
发表期刊	SCIENTIFIC REPORTS
卷号	6 期号:X 页码:e25431
摘要	A common pattern in dominance hierarchies is that some ranks result in higher levels of psychosocial stress than others. Such stress can lead to negative health outcomes, possibly through altered levels of stress hormones. The dominance rank-stress physiology relationship is known to vary between species; sometimes dominants show higher levels of glucocorticoid stress hormones, whereas in other cases subordinates show higher levels. It is less clear how this relationship varies between groups of different ages or cultures. In this study, we used long-term cortisol measurement methods to compare the effect of rank on cortisol levels in adult and adolescent male rhesus macaques. In the adult groups, subordinates had significantly higher cortisol levels. In the adolescents, no significant correlation between cortisol and status was found. Further analysis demonstrated that the adult hierarchy was stricter than that of the adolescents. Adult subordinates received extreme aggression more frequently than dominants, and this class of behavior was positively correlated with cortisol; by contrast, adolescents showed neither trend. Together, these findings provide evidence for a cortisol-rank relationship determined by social factors, namely, despotism of the group, and highlight the importance of group-specific social analysis when comparing or combining results obtained from different groups of animals.
资助者	We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas.
收录类别	SCI
语种	英语
资助者	We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas. ; We thank the radioimmuno-laboratory of the Second Affiliated Hospital of Kunming Medical College for technical assistance. This study was funded by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, and 81271495), the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047), the Yunnan Medical and Scientific Development Program (no. 2014NS043) and the Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/9793
专题	科研部门_神经系统编码（胡新天）科研部门_动物模型与人类重大疾病机理重点实验室中国科学院昆明灵长类研究中心
通讯作者	virgo1985712@163.com; qindong108@163.com; xthu@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650204, China 3.State Key Laboratory of Brain and Cognitive Science, Beijing, 100101, People’s Republic of China 4.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China 5.Institute of Biophysics, the Chinese Academy of Sciences, Beijing, 100101, People’s Republic of China 6.CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China 7.Department of Rehabilitation Medicine, the Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650021, China 8.The Ophthalmology Department, the Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650021, China
推荐引用方式 GB/T 7714	Feng XL*,Wu XJ,Morrill RJ,et al. Social correlates of the dominance rank and long-term cortisol levels in adolescent and adult male rhesus macaques (Macaca mulatta)[J]. SCIENTIFIC REPORTS,2016,6(X):e25431.
APA	Feng XL*.,Wu XJ.,Morrill RJ.,Li ZF.,Li CL.,...&xthu@mail.kiz.ac.cn.(2016).Social correlates of the dominance rank and long-term cortisol levels in adolescent and adult male rhesus macaques (Macaca mulatta).SCIENTIFIC REPORTS,6(X),e25431.
MLA	Feng XL*,et al."Social correlates of the dominance rank and long-term cortisol levels in adolescent and adult male rhesus macaques (Macaca mulatta)".SCIENTIFIC REPORTS 6.X(2016):e25431.

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