Reconstruction and applications of consensus yeast metabolic network based on RNA sequencing

KIZ OpenIR > 结构生物信息学

	Reconstruction and applications of consensus yeast metabolic network based on RNA sequencing
	Zhao YQ1; Wang YJ 2; Zou L 3; Huang JF1,4; zhaoyq@mail.kiz.ac.cn ; huangjf@mail.kiz.ac.cn
	2016
发表期刊	FEBS Open Bio
卷号	6 期号:4 页码:264-275
摘要	One practical application of genome-scale metabolic reconstructions is to interrogate multispecies relationships. Here, we report a consensus metabolic model in four yeast species (Saccharomyces cerevisiae, S. paradoxus, S. mikatae, and S. bayanus) by integrating metabolic network simulations with RNA sequencing (RNA-seq) datasets. We generated high-resolution transcriptome maps of four yeast species through de novo assembly and genome-guided approaches. The transcriptomes were annotated and applied to build the consensus metabolic network, which was verified using independent RNA-seq experiments. The expression profiles reveal that the genes involved in amino acid and lipid metabolism are highly coexpressed. The diverse phenotypic characteristics, such as cellular growth and gene deletions, can be simulated using the metabolic model. We also explored the applications of the consensus model in metabolic engineering using yeast-specific reactions and biofuel production as examples. Similar strategies will benefit communities studying genome-scale metabolic networks of other organisms.
关键词	Rna Sequencing Saccharomyces Species Metabolic Engineering Metabolic Network
资助者	This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100)
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语种	英语
资助者	This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100) ; This work was supported by the grants from National Natural Science Foundation of China (Grant No. 81400084; Grant No. 31123005), National Basic Research Program of China (2013CB835100)
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/9930
专题	结构生物信息学科研部门_动物模型与人类重大疾病机理重点实验室遗传资源与进化国家重点实验室
通讯作者	zhaoyq@mail.kiz.ac.cn; huangjf@mail.kiz.ac.cn
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan, China 3.Department of General Surgery, First People’s Hospital of Yunnan Province, Kunming, China 4.Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Zhao YQ*,Wang YJ,Zou L,et al. Reconstruction and applications of consensus yeast metabolic network based on RNA sequencing[J]. FEBS Open Bio,2016,6(4):264-275.
APA	Zhao YQ,Wang YJ,Zou L,Huang JF,zhaoyq@mail.kiz.ac.cn,&huangjf@mail.kiz.ac.cn.(2016).Reconstruction and applications of consensus yeast metabolic network based on RNA sequencing.FEBS Open Bio,6(4),264-275.
MLA	Zhao YQ*,et al."Reconstruction and applications of consensus yeast metabolic network based on RNA sequencing".FEBS Open Bio 6.4(2016):264-275.

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