Corticosterone regulates fear memory via Rac1 activity in the hippocampus

	Corticosterone regulates fear memory via Rac1 activity in the hippocampus
	Gan P 1,2,3; Ding ZY 3; Xu L3,4 ; Zhou QX3; Gan C 5; Mao RR*3 ; Zhou H 3; quxin_zhou@126.com, ganping yeow@hotmail.com
	2016
发表期刊	Psychoneuroendocrinology
卷号	71 期号:X 页码:86-93
摘要	Stressful events can generate enduring memories, which may induce certain psychiatric disorders such as post-traumatic stress disorder (PTSD). However, the underlying molecular mechanisms in these processes remain unclear. In this study, we examined whether the active form of the small G protein Rac1, Rac1-GTP, is involved in fear memory. Firstly, we detected the time course changes of Rac1-GTP after foot shocks (a strong stressor) and exogenous corticosterone (CORT) treatment. The data showed that stress and CORT induced the downregulation of Rac1-GTP in the hippocampus. Changes in the serum CORT level were negatively correlated with the level of Rac1-GTP. Additionally, a glucocorticoid receptor antagonist, RU38486, not only recovered the expression of Rac1-GTP but also impaired fear memory. Furthermore, systemic administration of NSC23766, an inhibitor of Rac1-GTP, improved fear memory at 1.5 and 24h. Therefore, Rac1 activity plays a critical role in stress-related cognition and may be a potential target in stress-related disorders.
关键词	Corticosterone Fear Memory Foot Shocks Hippocampus Rac1-gtp Stress
资助者	This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003).
收录类别	其他
语种	英语
资助者	This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). ; This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/9959
专题	科研部门_学习记忆的分子神经机制（徐林）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	quxin_zhou@126.com, ganping yeow@hotmail.com
作者单位	1.College of Life Sciences, Yunnan University, China 2.College of Basic Medicine, Kunming Medical University, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, and Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China 4.CAS Center for Excellence in Brain Science, 320 Yue Yang Road, Shanghai, 200031, China 5.Endocrinology Department, Second Affiliated Hospital, Kunming Medical University, Kunming, China
推荐引用方式 GB/T 7714	Gan P,Ding ZY,Xu L,et al. Corticosterone regulates fear memory via Rac1 activity in the hippocampus[J]. Psychoneuroendocrinology,2016,71(X):86-93.
APA	Gan P.,Ding ZY.,Xu L.,Zhou QX*.,Gan C.,...&quxin_zhou@126.com, ganping yeow@hotmail.com.(2016).Corticosterone regulates fear memory via Rac1 activity in the hippocampus.Psychoneuroendocrinology,71(X),86-93.
MLA	Gan P,et al."Corticosterone regulates fear memory via Rac1 activity in the hippocampus".Psychoneuroendocrinology 71.X(2016):86-93.

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