| Two Tor genes in the silkworm Bombyx mori | |
| Zhou S1; Zhou Q2; Liu Y1; Wang S1; Wen D1; He Q1; Wang W2; Bendena WG3; Li S*1; shengli@sippe.ac.cn | |
| 2010 | |
| 发表期刊 | INSECT MOLECULAR BIOLOGY
 |
| 卷号 | 19期号:6页码:727-735 |
| 合作性质 | 其它 |
| 摘要 | Target of rapamycin (TOR), a member of the phosphatidylinositol kinase-related kinase family, plays a critical role in the regulation of growth, metabolism, development and survival, at both the cellular and the organismal levels. Two paralogous Tor genes, BmTor1 and BmTor2, were identified as a pair of inverted repeats in the genome of the silkworm Bombyx mori. The synteny of BmTor1 and CG8360 indicates that BmTor1 is the orthologue while BmTor2 is a duplicate. Analyses of the two BmTor genes at both the nucleotide and amino acid levels reveal that they are evolutionally and structurally conserved. The two BmTor genes had similar expression patterns of tissue distribution with highest levels in the nervous system, and nearly identical developmental change profiles with maximal levels during the 4th-larval-moulting and the larval-pupal transition stages. Furthermore, both BmTor genes were up-regulated by either starvation or the moulting hormone 20-hydroxyecdysone (20E), while BmTor2 was more sensitive to both treatments than BmTor1. For the first time, we have identified two copies of the Tor gene in a higher eukaryote, which are induced by starvation and 20E during the larval moulting and the larval-pupal transition stage. |
| 关键词 | Starvation 20-hydroxyecdysone Bombyx Mori Tor Gene Duplication Fat Body |
| 资助者 | This study was supported by 2007AA10Z155, 30770271, KSCX-YW-N-009, and 2006CB943902, and the Hundred Talent Project to SL. ; This study was supported by 2007AA10Z155, 30770271, KSCX-YW-N-009, and 2006CB943902, and the Hundred Talent Project to SL. ; This study was supported by 2007AA10Z155, 30770271, KSCX-YW-N-009, and 2006CB943902, and the Hundred Talent Project to SL. ; This study was supported by 2007AA10Z155, 30770271, KSCX-YW-N-009, and 2006CB943902, and the Hundred Talent Project to SL. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This study was supported by 2007AA10Z155, 30770271, KSCX-YW-N-009, and 2006CB943902, and the Hundred Talent Project to SL. ; This study was supported by 2007AA10Z155, 30770271, KSCX-YW-N-009, and 2006CB943902, and the Hundred Talent Project to SL. ; This study was supported by 2007AA10Z155, 30770271, KSCX-YW-N-009, and 2006CB943902, and the Hundred Talent Project to SL. ; This study was supported by 2007AA10Z155, 30770271, KSCX-YW-N-009, and 2006CB943902, and the Hundred Talent Project to SL. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/353002/6546 |
| 专题 | 基因起源组 遗传资源与进化国家重点实验室 |
| 通讯作者 | shengli@sippe.ac.cn |
| 作者单位 | 1.Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Department of Biology, Queen’s University, Kingston, ON, Canada |
| 推荐引用方式 GB/T 7714 | Zhou S,Zhou Q,Liu Y,et al. Two Tor genes in the silkworm Bombyx mori[J]. INSECT MOLECULAR BIOLOGY,2010,19(6):727-735. |
| APA | Zhou S.,Zhou Q.,Liu Y.,Wang S.,Wen D.,...&shengli@sippe.ac.cn.(2010).Two Tor genes in the silkworm Bombyx mori.INSECT MOLECULAR BIOLOGY,19(6),727-735. |
| MLA | Zhou S,et al."Two Tor genes in the silkworm Bombyx mori".INSECT MOLECULAR BIOLOGY 19.6(2010):727-735. |
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