Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques

	Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques
	Xia HJ 1,2; Zhang GH 1; Ma JP 1,2; Dai ZX 1,2; Li SY 1,2; Han JB 1; Zheng YT*1; zhengyt@mail.kiz.ac.cn
	2010
发表期刊	RETROVIROLOGY
卷号	7 期号:X 页码:e102
合作性质	其它
摘要	Background: Several studies have demonstrated that SIV infection progresses more slowly to experimental AIDS in Chinese rhesus macaques (Ch Rhs) than in Indian rhesus macaques (Ind Rhs). Here we investigated the dynamic and functional changes in dendritic cell (DC) subsets in SIVmac239-infected Ch Rhs. Results: The numbers of both mDC and pDC strongly fluctuated but were not significantly changed during the acute and chronic phases of infection. However, the concentration of both poly (I: C)-induced IL-12 and HSV-1-induced IFN-alpha significantly increased in the acute phase of infection but returned to normal levels at the chronic phase of infection. The peak of IFN-alpha emerged earlier than that of IL-12, and it had a significantly positive correlation with IL-12, which indicated that IFN-alpha may initiate the immune activation. We also found that only the concentration of IFN-alpha was positively correlated with CD4+ T-cell counts, but it was negatively correlated with viral load. Conclusion: High levels of IFN-alpha in the early stage of infection may contribute to effective control of virus replication, and normal levels of IFN-alpha during chronic infection may help Ch Rhs resist the disease progression. The change in DC subsets dynamics and cytokine production may help further our understanding of why Ch Rhs are able to live longer without progressing to an AIDS-like illness.
资助者	This work was supported in part by grants from the National Basic Research Program of China (2006CB504208, 2006CB504302, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15, KSCX1-YW-10, KSCX2-YW-R-128, KSCX2-YW-R-185, KSCX2-YW-R-092), the Eleventh Five-Year Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-013, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2009ZX09103-414), and the “Western Light” Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2006CB504208, 2006CB504302, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15, KSCX1-YW-10, KSCX2-YW-R-128, KSCX2-YW-R-185, KSCX2-YW-R-092), the Eleventh Five-Year Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-013, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2009ZX09103-414), and the “Western Light” Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2006CB504208, 2006CB504302, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15, KSCX1-YW-10, KSCX2-YW-R-128, KSCX2-YW-R-185, KSCX2-YW-R-092), the Eleventh Five-Year Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-013, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2009ZX09103-414), and the “Western Light” Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2006CB504208, 2006CB504302, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15, KSCX1-YW-10, KSCX2-YW-R-128, KSCX2-YW-R-185, KSCX2-YW-R-092), the Eleventh Five-Year Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-013, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2009ZX09103-414), and the “Western Light” Projects of CAS.
收录类别	SCI
语种	英语
资助者	This work was supported in part by grants from the National Basic Research Program of China (2006CB504208, 2006CB504302, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15, KSCX1-YW-10, KSCX2-YW-R-128, KSCX2-YW-R-185, KSCX2-YW-R-092), the Eleventh Five-Year Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-013, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2009ZX09103-414), and the “Western Light” Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2006CB504208, 2006CB504302, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15, KSCX1-YW-10, KSCX2-YW-R-128, KSCX2-YW-R-185, KSCX2-YW-R-092), the Eleventh Five-Year Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-013, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2009ZX09103-414), and the “Western Light” Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2006CB504208, 2006CB504302, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15, KSCX1-YW-10, KSCX2-YW-R-128, KSCX2-YW-R-185, KSCX2-YW-R-092), the Eleventh Five-Year Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-013, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2009ZX09103-414), and the “Western Light” Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2006CB504208, 2006CB504302, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601), the Knowledge Innovation Program of CAS (KSCX1-YW-R-15, KSCX1-YW-10, KSCX2-YW-R-128, KSCX2-YW-R-185, KSCX2-YW-R-092), the Eleventh Five-Year Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-013, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2009ZX09103-414), and the “Western Light” Projects of CAS.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6557
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	zhengyt@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Xia HJ,Zhang GH,Ma JP,et al. Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques[J]. RETROVIROLOGY,2010,7(X):e102.
APA	Xia HJ.,Zhang GH.,Ma JP.,Dai ZX.,Li SY.,...&zhengyt@mail.kiz.ac.cn.(2010).Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques.RETROVIROLOGY,7(X),e102.
MLA	Xia HJ,et al."Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques".RETROVIROLOGY 7.X(2010):e102.

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