Effects of isolation after sexual experience on anxiety-like, depressive-like behaviors and affective states in male rats

	Effects of isolation after sexual experience on anxiety-like, depressive-like behaviors and affective states in male rats
	Wen F 1,2; Xu L*1,3; lxu@vip.163.com
	2010
发表期刊	CHINESE SCIENCE BULLETIN
卷号	55 期号:36 页码:4132-4142
合作性质	其它
摘要	Studies on social isolation have provided evidence for an enhanced anxiety-like phenotype, depressive-like symptoms and higher levels of 22-kHz ultrasonic vocalizations (USVs); whereas sexual experience could induce significant changes in affective states, decrease anxiety- and depressive-like responses. However, the behavioral and emotional alterations in male rats exposed to isolation after sexual experience remain poorly understood. Therefore, the present study examined anxiety- and depressive-like parameters, as well as USV emissions in male rats isolated for 1, 2, or 7 d following 1-week sexual (male-female paired housing) or social (male-male paired housing) interaction. Isolation for I d resulted in increased depressive-like symptoms, and 2-d isolation induced elevated anxiety-like behavior in sexually inexperienced rats, while rats with sexual experience exhibited comparable levels of emotionality at each isolation time. Moreover, isolated rats without sexual experience emitted less 22- and 50-kHz USVs, but sexually experienced rats exhibited similar affective states compared with control ones. These results suggested that prior sexual experience could have a modulatory effect on experimental rat emotional responses to isolation.
关键词	Social Isolation Sexual Experience Anxiety-like Depressive-like Ultrasonic Vocalization (Usv)
资助者	This work was supported by the National Basic Research Program of China (2009CB941302) and Major Scientific and Technological Special Project for “Significant New Drugs Creation” (2009ZX09501-030). ; This work was supported by the National Basic Research Program of China (2009CB941302) and Major Scientific and Technological Special Project for “Significant New Drugs Creation” (2009ZX09501-030). ; This work was supported by the National Basic Research Program of China (2009CB941302) and Major Scientific and Technological Special Project for “Significant New Drugs Creation” (2009ZX09501-030). ; This work was supported by the National Basic Research Program of China (2009CB941302) and Major Scientific and Technological Special Project for “Significant New Drugs Creation” (2009ZX09501-030).
收录类别	SCI
语种	英语
资助者	This work was supported by the National Basic Research Program of China (2009CB941302) and Major Scientific and Technological Special Project for “Significant New Drugs Creation” (2009ZX09501-030). ; This work was supported by the National Basic Research Program of China (2009CB941302) and Major Scientific and Technological Special Project for “Significant New Drugs Creation” (2009ZX09501-030). ; This work was supported by the National Basic Research Program of China (2009CB941302) and Major Scientific and Technological Special Project for “Significant New Drugs Creation” (2009ZX09501-030). ; This work was supported by the National Basic Research Program of China (2009CB941302) and Major Scientific and Technological Special Project for “Significant New Drugs Creation” (2009ZX09501-030).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6561
专题	科研部门_学习记忆的分子神经机制（徐林）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	lxu@vip.163.com
作者单位	1.Laboratory of Learning and Memory and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China 2.Graduate University of the Chinese Academy of Sciences, Beijing 100049, China 3.Mental Health Institute, the 2nd Hospital of Central South University, Changsha 410011, China
推荐引用方式 GB/T 7714	Wen F,Xu L*,lxu@vip.163.com. Effects of isolation after sexual experience on anxiety-like, depressive-like behaviors and affective states in male rats[J]. CHINESE SCIENCE BULLETIN,2010,55(36):4132-4142.
APA	Wen F,Xu L*,&lxu@vip.163.com.(2010).Effects of isolation after sexual experience on anxiety-like, depressive-like behaviors and affective states in male rats.CHINESE SCIENCE BULLETIN,55(36),4132-4142.
MLA	Wen F,et al."Effects of isolation after sexual experience on anxiety-like, depressive-like behaviors and affective states in male rats".CHINESE SCIENCE BULLETIN 55.36(2010):4132-4142.

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