Evolution of alternative splicing in newly evolved genes of Drosophila

KIZ OpenIR > 基因起源组（王文）

	Evolution of alternative splicing in newly evolved genes of Drosophila
	Zhan ZB 1,2; Ren JA 1,2; Zhang Y 1; Zhao RP 1; Yang SA 1; Wang W*1; wwang@mail.kiz.ac.cn
	2011
发表期刊	GENE
卷号	470 期号:1-2 页码:1-6
合作性质	其它
摘要	New gene origination is a fundamental process underlying evolution of biological diversity Although new genes usually evolve rapidly in sequences structure and expression the evolutionary pattern of alternative splicing (AS) in new genes and the molecular mechanisms involved in this alternation remain to be explored Here we used the new genes identified in the Drosophila melanogaster lineage to study alternation of AS and the possible functional consequences of these genes We found that new genes tended to exhibit low degree of AS though a few new genes were alternatively spliced Interestingly loss of introns in retroposed new genes can only account for one third of the low-level AS in new genes while partial gene duplication without AS exons and mutations in the duplicated AS exons/introns together have resulted in two-third AS losses in new genes indicating that reducing the degree of AS is a general trend in all categories of new genes Further investigations on tissue expression patterns of these new genes showed that those with AS alternation had a relatively lower expression level were expressed in fewer tissues and tended to be more likely expressed in testis than their parental genes All these observations imply that these new genes may have gained diverged structures and expression patterns from their parental genes after AS alternation
关键词	New Genes Alternative Splicing Gene Duplication Retroposition Expression Pattern
资助者	This work was supported by a CAS key grant (KSCX2-YW-N-060) and a NSFC key grant (No. 30623007) to W.W., and a NSFC grant for junior researchers to S.Y. (No. 30500283). ; This work was supported by a CAS key grant (KSCX2-YW-N-060) and a NSFC key grant (No. 30623007) to W.W., and a NSFC grant for junior researchers to S.Y. (No. 30500283). ; This work was supported by a CAS key grant (KSCX2-YW-N-060) and a NSFC key grant (No. 30623007) to W.W., and a NSFC grant for junior researchers to S.Y. (No. 30500283). ; This work was supported by a CAS key grant (KSCX2-YW-N-060) and a NSFC key grant (No. 30623007) to W.W., and a NSFC grant for junior researchers to S.Y. (No. 30500283).
收录类别	SCI
语种	英语
资助者	This work was supported by a CAS key grant (KSCX2-YW-N-060) and a NSFC key grant (No. 30623007) to W.W., and a NSFC grant for junior researchers to S.Y. (No. 30500283). ; This work was supported by a CAS key grant (KSCX2-YW-N-060) and a NSFC key grant (No. 30623007) to W.W., and a NSFC grant for junior researchers to S.Y. (No. 30500283). ; This work was supported by a CAS key grant (KSCX2-YW-N-060) and a NSFC key grant (No. 30623007) to W.W., and a NSFC grant for junior researchers to S.Y. (No. 30500283). ; This work was supported by a CAS key grant (KSCX2-YW-N-060) and a NSFC key grant (No. 30623007) to W.W., and a NSFC grant for junior researchers to S.Y. (No. 30500283).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6566
专题	基因起源组（王文）遗传资源与进化国家重点实验室
通讯作者	wwang@mail.kiz.ac.cn
作者单位	1.CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming, Yunnan 650223, China 2.Graduate School of Chinese Academy Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Zhan ZB,Ren JA,Zhang Y,et al. Evolution of alternative splicing in newly evolved genes of Drosophila[J]. GENE,2011,470(1-2):1-6.
APA	Zhan ZB.,Ren JA.,Zhang Y.,Zhao RP.,Yang SA.,...&wwang@mail.kiz.ac.cn.(2011).Evolution of alternative splicing in newly evolved genes of Drosophila.GENE,470(1-2),1-6.
MLA	Zhan ZB,et al."Evolution of alternative splicing in newly evolved genes of Drosophila".GENE 470.1-2(2011):1-6.

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