Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese

KIZ OpenIR > 科研部门 > 疾病机理遗传学和进化医学学科组（姚永刚）

	Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese
	Zhang W 1,3; Chen XG2; Gong W 1,4; Tang JS 2; Tan LW 2; Guo H 1,5; Yao YG1; chenxghn@gmail.com ; yaoyg@mail.kiz.ac.cn
	2010
发表期刊	BEHAVIORAL AND BRAIN FUNCTIONS
卷号	6 期号:X 页码:e75
合作性质	其它
摘要	Background: The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations. Methods: We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two reported single nucleotide polymorphisms (SNPs) confer susceptibility to schizophrenia in Chinese. Results: Allele, genotype and haplotype comparison between the case and control groups showed no statistical significance, suggesting no association between the NDUFV2 gene promoter variants and schizophrenia in Han Chinese. Conclusion: The role of NDUFV2 played in schizophrenia needs to be further studied. Different racial background and/or population substructure might account for the inconsistent results between studies
资助者	This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301). ; This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301). ; This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301). ; This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301).
收录类别	SCI
语种	英语
资助者	This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301). ; This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301). ; This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301). ; This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6574
专题	科研部门_疾病机理遗传学和进化医学学科组（姚永刚）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	chenxghn@gmail.com; yaoyg@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.The Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 4.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China 5.Department of Cardiology, Calmette Hospital, Kunming Medical College, Kunming, Yunnan 650011, China
推荐引用方式 GB/T 7714	Zhang W,Chen XG*,Gong W,et al. Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2010,6(X):e75.
APA	Zhang W.,Chen XG*.,Gong W.,Tang JS.,Tan LW.,...&yaoyg@mail.kiz.ac.cn.(2010).Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese.BEHAVIORAL AND BRAIN FUNCTIONS,6(X),e75.
MLA	Zhang W,et al."Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese".BEHAVIORAL AND BRAIN FUNCTIONS 6.X(2010):e75.

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