There are Abundant Antimicrobial Peptides in Brains of Two Kinds of Bombina Toads

	There are Abundant Antimicrobial Peptides in Brains of Two Kinds of Bombina Toads
	Liu R 1; Liu HA 2; Ma YF 2; Wu J 2; Yang HL 2; Ye HH 3; Lai R*1,2; rlai72@njau.edu.cn
	2011
发表期刊	JOURNAL OF PROTEOME RESEARCH
卷号	10 期号:4 页码:1806-1815
合作性质	其它
摘要	It is well-known that there is a large amount of antimicrobial peptides in amphibian skins but few antimicrobial peptides are found in amphibian brains. Twenty-two and four antimicrobial peptides were purified and characterized from the brain homogenate of Bombina maxima and B. microdeladigitora, respectively. One hundred fifty-eight cDNA clones encoding 79 antimicrobial peptides were isolated from brain cDNA libraries of B. maxima and B. microdeladigitora. These antimicrobial peptides belong to two peptide groups (maximin and maximin-H). Twenty of them are identical to previously reported antimicrobial peptides (maximin 1-8, 10, 11, maximin H1, 3-5,7, 9, 10, 12, 15, 16) from B. maxima skin secretions. Fifty nine of them are novel antimicrobial peptides. Some of these antimicrobial peptides showed strong antimicrobial activities against tested microorganism strains including Gram-positive and -negative bacteria and fungi. The current diversity in peptide coding cDNA sequences is, to our knowledge, the most extreme yet described for any animal brains. The extreme diversity may give rise to interest to prospect the actual funcitons of antimicrobial peptides in amphibian brains.
关键词	Antimicrobial Peptides Brain Amphibian
资助者	This work was supported by Chinese National Natural 455 Science Foundation (30830021, 30800185, 31025025) and the 456 Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural 455 Science Foundation (30830021, 30800185, 31025025) and the 456 Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural 455 Science Foundation (30830021, 30800185, 31025025) and the 456 Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural 455 Science Foundation (30830021, 30800185, 31025025) and the 456 Ministry of Science and Technology (2010CB529800).
收录类别	SCI
语种	英语
资助者	This work was supported by Chinese National Natural 455 Science Foundation (30830021, 30800185, 31025025) and the 456 Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural 455 Science Foundation (30830021, 30800185, 31025025) and the 456 Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural 455 Science Foundation (30830021, 30800185, 31025025) and the 456 Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural 455 Science Foundation (30830021, 30800185, 31025025) and the 456 Ministry of Science and Technology (2010CB529800).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6615
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	rlai72@njau.edu.cn
作者单位	1.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.Beijing Institute of Microbiology and Epidemiology, the Academy of Military Medical Sciences, China
推荐引用方式 GB/T 7714	Liu R,Liu HA,Ma YF,et al. There are Abundant Antimicrobial Peptides in Brains of Two Kinds of Bombina Toads[J]. JOURNAL OF PROTEOME RESEARCH,2011,10(4):1806-1815.
APA	Liu R.,Liu HA.,Ma YF.,Wu J.,Yang HL.,...&rlai72@njau.edu.cn.(2011).There are Abundant Antimicrobial Peptides in Brains of Two Kinds of Bombina Toads.JOURNAL OF PROTEOME RESEARCH,10(4),1806-1815.
MLA	Liu R,et al."There are Abundant Antimicrobial Peptides in Brains of Two Kinds of Bombina Toads".JOURNAL OF PROTEOME RESEARCH 10.4(2011):1806-1815.

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