Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates

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	Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates
	Chen M 1,4; Zou M 1,4; Fu BD 1,4; Li X 2; Vibranovski MD 3; Gan XN 1,4; Wang DQ 1,4,5; Wang W 2; Long MY3; He SP1; mlong@uchicago.edu ; clad@ihb.ac.cn
	2011
发表期刊	PLOS ONE
卷号	6 期号:7 页码:e21466
合作性质	其它
摘要	The role of RNA-based duplication, or retroposition, in the evolution of new gene functions in mammals, plants, and Drosophila has been widely reported. However, little is known about RNA-based duplication in non-mammalian chordates. In this study, we screened ten non-mammalian chordate genomes for retrocopies and investigated their evolutionary patterns. We identified numerous retrocopies in these species. Examination of the age distribution of these retrocopies revealed no burst of young retrocopies in ancient chordate species. Upon comparing these non-mammalian chordate species to the mammalian species, we observed that a larger fraction of the non-mammalian retrocopies was under strong evolutionary constraints than mammalian retrocopies are, as evidenced by signals of purifying selection and expression profiles. For the Western clawed frog, Medaka, and Sea squirt, many retrogenes have evolved gonad and brain expression patterns, similar to what was observed in human. Testing of retrogene movement in the Medaka genome, where the nascent sex chrosomes have been well assembled, did not reveal any significant gene movement. Taken together, our analyses demonstrate that RNA-based duplication generates many functional genes and can make a significant contribution to the evolution of non-mammalian genomes.
资助者	This work was supported by grants from National Natural Science Foundation of China [2007CB411601] (http://www.nsfc.gov.cn/Portal0/default124. htm). ; This work was supported by grants from National Natural Science Foundation of China [2007CB411601] (http://www.nsfc.gov.cn/Portal0/default124. htm). ; This work was supported by grants from National Natural Science Foundation of China [2007CB411601] (http://www.nsfc.gov.cn/Portal0/default124. htm). ; This work was supported by grants from National Natural Science Foundation of China [2007CB411601] (http://www.nsfc.gov.cn/Portal0/default124. htm).
收录类别	SCI
语种	英语
资助者	This work was supported by grants from National Natural Science Foundation of China [2007CB411601] (http://www.nsfc.gov.cn/Portal0/default124. htm). ; This work was supported by grants from National Natural Science Foundation of China [2007CB411601] (http://www.nsfc.gov.cn/Portal0/default124. htm). ; This work was supported by grants from National Natural Science Foundation of China [2007CB411601] (http://www.nsfc.gov.cn/Portal0/default124. htm). ; This work was supported by grants from National Natural Science Foundation of China [2007CB411601] (http://www.nsfc.gov.cn/Portal0/default124. htm).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6648
专题	基因起源组
通讯作者	mlong@uchicago.edu; clad@ihb.ac.cn
作者单位	1.Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, People’s Republic of China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, People’s Republic of China 3.Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America 4.Graduate University of Chinese Academy of Sciences, Beijing, People’s Republic of China 5.Yangtze River Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Wuhan, People’s Republic of China
推荐引用方式 GB/T 7714	Chen M,Zou M,Fu BD,et al. Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates[J]. PLOS ONE,2011,6(7):e21466.
APA	Chen M.,Zou M.,Fu BD.,Li X.,Vibranovski MD.,...&clad@ihb.ac.cn.(2011).Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates.PLOS ONE,6(7),e21466.
MLA	Chen M,et al."Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates".PLOS ONE 6.7(2011):e21466.

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2011081201.pdf（373KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文