Proteomic Analysis of Skin Defensive Factors of Tree Frog Hyla simplex

	Proteomic Analysis of Skin Defensive Factors of Tree Frog Hyla simplex
	Wu J 1,5; Liu H 1,5; Yang HL 1,5; Yu HN 4; You DW 1; Ma YF 1; Ye HH 3; Lai R*1,2; rlai@mail.kiz.ac.cn
	2011
发表期刊	JOURNAL OF PROTEOME RESEARCH
卷号	10 期号:9 页码:4230-4240
合作性质	其它
摘要	Tree frogs produce a variety of skin defensive chemicals against many biotic and abiotic risk factors for their everyday survival. By proteomics or peptidomics and coupling transcriptome analysis with pharmacological testings, 27 peptides or proteins belonging to 9 families, which act mainly as defensive functions, were identified and characterized from skin secretions of the tree frog, Hyla simplex. They are: (1) a novel family of peptides with EGF- and VEGF-releasing activities; (2) a novel family of analgesic peptides; (3) a family of neurotoxins acting on sodium channel; (4) a snake venom-like presynaptically active neurotoxin; (5) a snake venom-like neurotoxin targeting cyclic nucleotide-gated ion channels:, (6) a tachykinin-like peptide, which is the first report from tree frogs; (7) two antimicrobial peptides; (8) a alpha-l-antitrypsin-like serpin; and (9) a wasp venom-like toxin with serine protease inhibitors activity. Families of 1, 2, 4, 5, and 8 proteins or peptides are first reported in amphibians. The chemical array in the tree frog skin shares some similarities with snake venoms. Most of these components in this tree frog help defend against predators, heal wounds, or attenuate suffering.
关键词	Amphibian Hyla Skin Arboreal Defense
资助者	This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091), and the Ministry of Agriculture (2009ZX08009-159B). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091), and the Ministry of Agriculture (2009ZX08009-159B). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091), and the Ministry of Agriculture (2009ZX08009-159B). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091), and the Ministry of Agriculture (2009ZX08009-159B).
收录类别	SCI
语种	英语
资助者	This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091), and the Ministry of Agriculture (2009ZX08009-159B). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091), and the Ministry of Agriculture (2009ZX08009-159B). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091), and the Ministry of Agriculture (2009ZX08009-159B). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091), and the Ministry of Agriculture (2009ZX08009-159B).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6792
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	rlai@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 3.Institute of Microbiology and Epidemiology, the Academy of Military Medical Sciences, Beijing 100071, China 4.Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116023, China 5.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China
推荐引用方式 GB/T 7714	Wu J,Liu H,Yang HL,et al. Proteomic Analysis of Skin Defensive Factors of Tree Frog Hyla simplex[J]. JOURNAL OF PROTEOME RESEARCH,2011,10(9):4230-4240.
APA	Wu J.,Liu H.,Yang HL.,Yu HN.,You DW.,...&rlai@mail.kiz.ac.cn.(2011).Proteomic Analysis of Skin Defensive Factors of Tree Frog Hyla simplex.JOURNAL OF PROTEOME RESEARCH,10(9),4230-4240.
MLA	Wu J,et al."Proteomic Analysis of Skin Defensive Factors of Tree Frog Hyla simplex".JOURNAL OF PROTEOME RESEARCH 10.9(2011):4230-4240.

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