Anti HIV-1 Agents 7. Discovery of 1-Hydroxy-4-chloro-9,10-anthraquinone Derivatives as New HIV-1 Inhibitors in Vitro

	Anti HIV-1 Agents 7. Discovery of 1-Hydroxy-4-chloro-9,10-anthraquinone Derivatives as New HIV-1 Inhibitors in Vitro
	Huang N 1,3; Wang Q 2; Yang LM 1; Xu H2; Zheng YT1; orgxuhui@nwsuaf.edu.cn, zhengyt@mail.kiz.ac.cn
	2011
发表期刊	LETTERS IN DRUG DESIGN & DISCOVERY
卷号	8 期号:7 页码:602-605
合作性质	其它
摘要	In continuation of our program aimed at the discovery and development of anti-HIV-1 agents, six 1-hydroxy-4-chloro-9, 10-anthraquinone derivatives (3-8) were prepared and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Compounds 4 and 6 exhibited the potent anti-HIV-1 activities with EC(50) values of 9.81 and 17.90 mu g/mL, and TI values of >13.58 and >11.17, respectively. It demonstrated that introduction of the alkylacyloxy or alkylsulfonyloxy group at the 1-position of 1-hydroxy-4-chloro-9,10-anthraquinone could afford the more promising and potent compound than that having arylacyloxy or arylsulfonyloxy one.
关键词	Human Immunodeficiency Virus-1 Inhibitor Acquired Immunodeficiency Syndrome 1-hydroxy-4-chloro-9 10-anthraquinone
资助者	m New Century Excellent University Talents, State Edu- cation Ministry of China (NCET-06-0868), and the Key Pro- ject of Chinese Ministry of Education (No. 107105). We also would like to acknowledge the National Basic Research Pro- gram of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029, 2008ZX10005-005), 863 Program (2006AA020602), Scientific and Technological Projects of Yunnan (2007BC006), the Knowledge Innovation Program of CAS (KSCX2-YW-R-185, KSCX1-YW-10), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; m New Century Excellent University Talents, State Edu- cation Ministry of China (NCET-06-0868), and the Key Pro- ject of Chinese Ministry of Education (No. 107105). We also would like to acknowledge the National Basic Research Pro- gram of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029, 2008ZX10005-005), 863 Program (2006AA020602), Scientific and Technological Projects of Yunnan (2007BC006), the Knowledge Innovation Program of CAS (KSCX2-YW-R-185, KSCX1-YW-10), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; m New Century Excellent University Talents, State Edu- cation Ministry of China (NCET-06-0868), and the Key Pro- ject of Chinese Ministry of Education (No. 107105). We also would like to acknowledge the National Basic Research Pro- gram of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029, 2008ZX10005-005), 863 Program (2006AA020602), Scientific and Technological Projects of Yunnan (2007BC006), the Knowledge Innovation Program of CAS (KSCX2-YW-R-185, KSCX1-YW-10), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; m New Century Excellent University Talents, State Edu- cation Ministry of China (NCET-06-0868), and the Key Pro- ject of Chinese Ministry of Education (No. 107105). We also would like to acknowledge the National Basic Research Pro- gram of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029, 2008ZX10005-005), 863 Program (2006AA020602), Scientific and Technological Projects of Yunnan (2007BC006), the Knowledge Innovation Program of CAS (KSCX2-YW-R-185, KSCX1-YW-10), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses.
收录类别	SCI
语种	英语
资助者	m New Century Excellent University Talents, State Edu- cation Ministry of China (NCET-06-0868), and the Key Pro- ject of Chinese Ministry of Education (No. 107105). We also would like to acknowledge the National Basic Research Pro- gram of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029, 2008ZX10005-005), 863 Program (2006AA020602), Scientific and Technological Projects of Yunnan (2007BC006), the Knowledge Innovation Program of CAS (KSCX2-YW-R-185, KSCX1-YW-10), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; m New Century Excellent University Talents, State Edu- cation Ministry of China (NCET-06-0868), and the Key Pro- ject of Chinese Ministry of Education (No. 107105). We also would like to acknowledge the National Basic Research Pro- gram of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029, 2008ZX10005-005), 863 Program (2006AA020602), Scientific and Technological Projects of Yunnan (2007BC006), the Knowledge Innovation Program of CAS (KSCX2-YW-R-185, KSCX1-YW-10), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; m New Century Excellent University Talents, State Edu- cation Ministry of China (NCET-06-0868), and the Key Pro- ject of Chinese Ministry of Education (No. 107105). We also would like to acknowledge the National Basic Research Pro- gram of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029, 2008ZX10005-005), 863 Program (2006AA020602), Scientific and Technological Projects of Yunnan (2007BC006), the Knowledge Innovation Program of CAS (KSCX2-YW-R-185, KSCX1-YW-10), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses. ; m New Century Excellent University Talents, State Edu- cation Ministry of China (NCET-06-0868), and the Key Pro- ject of Chinese Ministry of Education (No. 107105). We also would like to acknowledge the National Basic Research Pro- gram of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029, 2008ZX10005-005), 863 Program (2006AA020602), Scientific and Technological Projects of Yunnan (2007BC006), the Knowledge Innovation Program of CAS (KSCX2-YW-R-185, KSCX1-YW-10), and the MRC AIDS Research Project and the NIH AIDS Research and Reference Reagent Program for providing cell lines and viruses.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6793
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	orgxuhui@nwsuaf.edu.cn, zhengyt@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P. R. China 2.Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, P. R. China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Huang N,Wang Q,Yang LM,et al. Anti HIV-1 Agents 7. Discovery of 1-Hydroxy-4-chloro-9,10-anthraquinone Derivatives as New HIV-1 Inhibitors in Vitro[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2011,8(7):602-605.
APA	Huang N,Wang Q,Yang LM,Xu H,Zheng YT,&orgxuhui@nwsuaf.edu.cn, zhengyt@mail.kiz.ac.cn.(2011).Anti HIV-1 Agents 7. Discovery of 1-Hydroxy-4-chloro-9,10-anthraquinone Derivatives as New HIV-1 Inhibitors in Vitro.LETTERS IN DRUG DESIGN & DISCOVERY,8(7),602-605.
MLA	Huang N,et al."Anti HIV-1 Agents 7. Discovery of 1-Hydroxy-4-chloro-9,10-anthraquinone Derivatives as New HIV-1 Inhibitors in Vitro".LETTERS IN DRUG DESIGN & DISCOVERY 8.7(2011):602-605.

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