Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes

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	Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes
	Chen Y 1,2; Ding Y 1,2; Zhang ZM 1,2; Wang W 1; Chen JY 3; Ueno NT 4; Mao BY*1; mao@mail.kiz.ac.cn
	2011
发表期刊	JOURNAL OF GENETICS AND GENOMICS
卷号	38 期号:12 页码:577-584
合作性质	其它
摘要	The evolution of the central nervous system (CNS) is one of the most striking changes during the transition from invertebrates to vertebrates. As a major source of genetic novelties, gene duplication might play an important role in the functional innovation of vertebrate CNS. In this study, we focused on a group of CNS-biased genes that duplicated during early vertebrate evolution. We investigated the tempo-spatial expression patterns of 33 duplicate gene families and their orthologs during the embryonic development of the vertebrate Xenopus laevis and the cephalochordate Brachiostoma belcheri. Almost all the identified duplicate genes are differentially expressed in the CNS in Xenopus embryos, and more than 50% and 30% duplicate genes are expressed in the telencephalon and mid-hindbrain boundary, respectively, which are mostly considered as two innovations in the vertebrate CNS. Interestingly, more than 50% of the amphioxus orthologs do not show apparent expression in the CNS in amphioxus embryos as detected by in situ hybridization, indicating that some of the vertebrate CNS-biased duplicate genes might arise from non-CNS genes in invertebrates. Our data accentuate the functional contribution of gene duplication in the CNS evolution of vertebrate and uncover an invertebrate non-CNS history for some vertebrate CNS-biased duplicate genes.
关键词	Central Nervous System Evolution Gene Duplication Expression Pattern Amphioxus Xenopus
资助者	This work was supported by the grants from the Innovation Project of Chinese Academy of Sciences (No. KSCX2-YW-R- 090) and the Key State Research Program from the Ministry of Science and Technology of China (No. 2007CB947201). ; This work was supported by the grants from the Innovation Project of Chinese Academy of Sciences (No. KSCX2-YW-R- 090) and the Key State Research Program from the Ministry of Science and Technology of China (No. 2007CB947201). ; This work was supported by the grants from the Innovation Project of Chinese Academy of Sciences (No. KSCX2-YW-R- 090) and the Key State Research Program from the Ministry of Science and Technology of China (No. 2007CB947201). ; This work was supported by the grants from the Innovation Project of Chinese Academy of Sciences (No. KSCX2-YW-R- 090) and the Key State Research Program from the Ministry of Science and Technology of China (No. 2007CB947201).
收录类别	SCI
语种	英语
资助者	This work was supported by the grants from the Innovation Project of Chinese Academy of Sciences (No. KSCX2-YW-R- 090) and the Key State Research Program from the Ministry of Science and Technology of China (No. 2007CB947201). ; This work was supported by the grants from the Innovation Project of Chinese Academy of Sciences (No. KSCX2-YW-R- 090) and the Key State Research Program from the Ministry of Science and Technology of China (No. 2007CB947201). ; This work was supported by the grants from the Innovation Project of Chinese Academy of Sciences (No. KSCX2-YW-R- 090) and the Key State Research Program from the Ministry of Science and Technology of China (No. 2007CB947201). ; This work was supported by the grants from the Innovation Project of Chinese Academy of Sciences (No. KSCX2-YW-R- 090) and the Key State Research Program from the Ministry of Science and Technology of China (No. 2007CB947201).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6863
专题	科研部门_发育生物学（毛炳宇）遗传资源与进化国家重点实验室基因起源组
通讯作者	mao@mail.kiz.ac.cn
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Jiaochang East Road 32, Kunming 650223, China 2.Graduate University of Chinese Academy of Sciences, Beijing 100049, China 3.School of Life Sciences, Nanjing University, Hankou Road, Nanjing, Jiangsu 210093, China 4.Division of Morphogenesis, National Institute for Basic Biology, Nishigonaka 38, Myodaiji, Okazaki, Aichi 444-8585, Japan
推荐引用方式 GB/T 7714	Chen Y,Ding Y,Zhang ZM,et al. Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes[J]. JOURNAL OF GENETICS AND GENOMICS,2011,38(12):577-584.
APA	Chen Y.,Ding Y.,Zhang ZM.,Wang W.,Chen JY.,...&mao@mail.kiz.ac.cn.(2011).Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes.JOURNAL OF GENETICS AND GENOMICS,38(12),577-584.
MLA	Chen Y,et al."Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes".JOURNAL OF GENETICS AND GENOMICS 38.12(2011):577-584.

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