| A systematic analysis of heart transcriptome highlights divergent cardiovascular disease pathways between animal models and humans | |
| Zhao YQ1,2; Sheng ZZ1,2; Huang JF*1,3; huangjf@mail.kiz.ac.cn | |
| 2012 | |
| 发表期刊 | MOLECULAR BIOSYSTEMS
 |
| 卷号 | 8期号:2页码:504-510 |
| 合作性质 | 其它 |
| 摘要 | Animal models have been extensively used in the study of cardiovascular disease (CVD) and have provided important insights into disease pathogenesis and drug development. However, the level of conservation of gene expression patterns of the orthologous genes between human and animal models was unclear. To address this issue, we compared the expression of orthologous genes in human and four models (rhesus, rat, mouse and dog), based on 42 normal heart samples with high quality gene expression data. The results show that the global expression profiles between animal model and human orthologous genes are highly preserved. The phylogenetic tree inferred from the gene expression profiles has similar topology to that of the species tree. However, differentially expressed genes (DEGs) between human and each model were identified and these four gene datasets are enriched with different molecular functions, including hormone-receptor binding and geranyl transferase activity. The 65 overlapped DEGs between four sets are involved in thyroid cancer, proteasome systems, aminoacyl-tRNA biosynthesis and GST (Glycine, Serine and Threonine) metabolism, of which functions are divergent between models and humans. In addition, 46.2% (30/65) of the communal genes have been experimentally proven to be associated with cardiovascular disease. Next, we constructed a co-expression network based on intra-and inter-species variation, to elucidate the altered network organization. It indicates that these DEGs evolved as modules rather than independently. The integrated heart transcriptome data should provide a valuable resource for the in-depth understanding of cardiology and the development of cardiovascular disease models |
| 资助者 | This work was supported by the National Basic Research Program of China (Grant No. 2009CB941300; 2007CB815705), the National Natural Science Foundation of China (Grant No. 30623007) and the Chinese Academy of Sciences (Grant No. 2007211311091) for JFH. ; This work was supported by the National Basic Research Program of China (Grant No. 2009CB941300; 2007CB815705), the National Natural Science Foundation of China (Grant No. 30623007) and the Chinese Academy of Sciences (Grant No. 2007211311091) for JFH. ; This work was supported by the National Basic Research Program of China (Grant No. 2009CB941300; 2007CB815705), the National Natural Science Foundation of China (Grant No. 30623007) and the Chinese Academy of Sciences (Grant No. 2007211311091) for JFH. ; This work was supported by the National Basic Research Program of China (Grant No. 2009CB941300; 2007CB815705), the National Natural Science Foundation of China (Grant No. 30623007) and the Chinese Academy of Sciences (Grant No. 2007211311091) for JFH. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by the National Basic Research Program of China (Grant No. 2009CB941300; 2007CB815705), the National Natural Science Foundation of China (Grant No. 30623007) and the Chinese Academy of Sciences (Grant No. 2007211311091) for JFH. ; This work was supported by the National Basic Research Program of China (Grant No. 2009CB941300; 2007CB815705), the National Natural Science Foundation of China (Grant No. 30623007) and the Chinese Academy of Sciences (Grant No. 2007211311091) for JFH. ; This work was supported by the National Basic Research Program of China (Grant No. 2009CB941300; 2007CB815705), the National Natural Science Foundation of China (Grant No. 30623007) and the Chinese Academy of Sciences (Grant No. 2007211311091) for JFH. ; This work was supported by the National Basic Research Program of China (Grant No. 2009CB941300; 2007CB815705), the National Natural Science Foundation of China (Grant No. 30623007) and the Chinese Academy of Sciences (Grant No. 2007211311091) for JFH. |
| WOS记录号 | WOS:000298994900010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/353002/6898 |
| 专题 | 结构生物信息学 遗传资源与进化国家重点实验室 |
| 通讯作者 | huangjf@mail.kiz.ac.cn |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32, Eastern Jiaochang Road, Kunming, Yunnan 650223, China 2.Graduate School of Chinese Academy of Sciences, Beijing 100039, China 3.Kunming Institute of Zoology-Chinese University of Hongkong Joint Research Center for Bio-resources and Human Disease Mechanisms, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Zhao YQ,Sheng ZZ,Huang JF*,et al. A systematic analysis of heart transcriptome highlights divergent cardiovascular disease pathways between animal models and humans[J]. MOLECULAR BIOSYSTEMS,2012,8(2):504-510. |
| APA | Zhao YQ,Sheng ZZ,Huang JF*,&huangjf@mail.kiz.ac.cn.(2012).A systematic analysis of heart transcriptome highlights divergent cardiovascular disease pathways between animal models and humans.MOLECULAR BIOSYSTEMS,8(2),504-510. |
| MLA | Zhao YQ,et al."A systematic analysis of heart transcriptome highlights divergent cardiovascular disease pathways between animal models and humans".MOLECULAR BIOSYSTEMS 8.2(2012):504-510. |
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| 2012032021.pdf（2162KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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