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Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 111
作者:  Luo, D;  Luo, RH;  Wang, WL;  Deng, R;  Wang, SR;  Ma, XY;  Pu, CL;  Liu, YY;  Zhang, HJ;  Yu, S;  Huang, Q;  Yang, LM;  Tong, Y;  Zheng, YT;  Li, R
Adobe PDF(5020Kb)  |  收藏  |  浏览/下载：153/0  |  提交时间：2025/04/09
Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 11, 页码: 7421-7437
作者:  He, J;  Wang, LZ;  Mi, DZ;  Guan, T;  Liu, WJ;  He, P;  Gu, HJ;  Li, YZ;  Peng, YR;  Jia, AQ;  Chen, CS;  Chen, YH
Adobe PDF(7437Kb)  |  收藏  |  浏览/下载：86/0  |  提交时间：2024/06/21
Discovery and structure-activity relationship studies of novel a-ketoamide derivatives targeting the SARS-CoV-2 main protease 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259
作者:  Huang, C;  Zeng, R;  Qiao, JX;  Quan, BX;  Luo, RH;  Huang, Q;  Guo, NH;  Li, YY;  Long, XY;  Ma, RG;  Xia, AJ;  Fang, Z;  Wang, YF;  Li, YS;  Zheng, YT;  Li, LL;  Lei, J;  Yang, SY
Adobe PDF(4197Kb)  |  收藏  |  浏览/下载：146/0  |  提交时间：2024/06/21
Novel Triazolopyridine-Based BRD4 Inhibitors as Potent HIV-1 Latency Reversing Agents 期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 15, 期号: 1, 页码: 60-68
作者:  Wang, YK;  Huang, XS;  Sun, H;  Ma, MD;  Yu, HP;  Hu, W;  Li, ZY;  Li, Z;  Luo, RH;  Tian, RR;  Xiao, TF;  Yang, LM;  Zheng, YT;  Li, X
Adobe PDF(2661Kb)  |  收藏  |  浏览/下载：23/0  |  提交时间：2024/06/21
Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243
作者:  Qian, WY;  Zhou, GF;  Ge, XT;  Xue, JX;  Zheng, CB;  Yang, LM;  Gu, XR;  Li, CY;  Xiong, SD;  Zheng, YT;  Zhou, GC
Adobe PDF(4648Kb)  |  收藏  |  浏览/下载：41/0  |  提交时间：2023/04/18
Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 227
作者:  Wang, YT;  Long, XY;  Ding, X;  Fan, SR;  Cai, JY;  Yang, BJ;  Zhang, XF;  Luo, RH;  Yang, L;  Ruan, T;  Ren, J;  Jing, CX;  Zheng, YT;  Hao, XJ;  Chen, DZ
Adobe PDF(2966Kb)  |  收藏  |  浏览/下载：179/0  |  提交时间：2023/04/18
Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 24, 页码: 16526-16540
作者:  Xie, X;  Zheng, YG;  Chen, H;  Li, J;  Luo, RH;  Chen, L;  Zheng, CB;  Zhang, SR;  Peng, PF;  Ma, D;  Yang, LM;  Zheng, YT;  Liu, H;  Wang, J
Adobe PDF(4030Kb)  |  收藏  |  浏览/下载：255/0  |  提交时间：2023/04/18
Lead optimization to improve the antiviral potency of 2-aminobenzamide derivatives targeting HIV-1 Vif-A3G axis 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224
作者:  Zhong, XX;  Luo, RH;  Yan, GY;  Ran, K;  Shan, HF;  Yang, J;  Liu, YY;  Yu, S;  Pu, CL;  Zheng, YT;  Li, R
Adobe PDF(1183Kb)  |  收藏  |  浏览/下载：164/0  |  提交时间：2023/04/18
Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca(v)3.1 Low Voltage Gated Ca2+ Channel 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 4, 页码: 1709-1716
作者:  Ye, Yan-Song;  Li, Wen-Yan;  Du, Shu-Zong;  Yang, Jian;  Nian, Yin;  Xu, Gang
Adobe PDF(2604Kb)  |  收藏  |  浏览/下载：2916/0  |  提交时间：2021/11/09
Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca(v)3.1 Low Voltage Gated Ca2+ Channel 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 4, 页码: 1709-1716
作者:  Ye, YS;  Li, WY;  Du, SZ;  Yang, J;  Nian, Y;  Xu, G
Adobe PDF(1104Kb)  |  收藏  |  浏览/下载：1327/0  |  提交时间：2023/04/18