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Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca(v)3.1 Low Voltage Gated Ca2+ Channel 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 4, 页码: 1709-1716
作者:  Ye, Yan-Song;  Li, Wen-Yan;  Du, Shu-Zong;  Yang, Jian;  Nian, Yin;  Xu, Gang
Adobe PDF(2604Kb)  |  收藏  |  浏览/下载:1266/0  |  提交时间:2021/11/09
Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors 期刊论文
ORGANIC LETTERS, 2020, 卷号: 22, 期号: 16, 页码: 6339-6343
作者:  Ye, Yan-Song;  Du, Shu-Zong;  Jiang, Na-Na;  Xu, Hong-Xi;  Yang, Jian;  Fu, Wen-Wei;  Nian, Yin;  Xu, Gang
Adobe PDF(1634Kb)  |  收藏  |  浏览/下载:1264/0  |  提交时间:2021/11/09
Scholarinine A, a N-3 type caged-monoterpene indole alkaloid as Ca(v)3.1 T-type calcium channel inhibitor from Alstonia scholaris 期刊论文
TETRAHEDRON LETTERS, 2020, 卷号: 61, 期号: 1
作者:  Zhan, Rui;  Du, Shu-Zong;  Duan, Zhi-Hang;  Nian, Yin;  Chen, Ye-Gao
Adobe PDF(690Kb)  |  收藏  |  浏览/下载:1256/0  |  提交时间:2021/11/09
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 卷号: 581, 期号: 7808, 页码: 329
作者:  Wang Lie;  Qian Hongwu;  Nian Yin;  Han Yimo;  Ren Zhenning;  Zhang Hanzhi;  Hu Liya;  Prasad, B. V. Venkataram;  Laganowsky, Arthur;  Yan Nieng;  Zhou Ming
Adobe PDF(21047Kb)  |  收藏  |  浏览/下载:1293/0  |  提交时间:2021/11/09
Pepluanols C-D, Two Diterpenoids with Two Skeletons from Euphorbia peplus. 期刊论文
Organic Letters, 2018, 期号: 20, 页码: 3074−3078
作者:  Luo-Sheng Wan;  Ming-Hua Qiu;  Xing-Rong Peng;  Li-Dong Shao;  Xiao-Nian Li;  Jian Yang;  Ming Zhou
Adobe PDF(995Kb)  |  收藏  |  浏览/下载:1299/0  |  提交时间:2018/09/27
Structure of an EIIC sugar transporter trapped in an inward-facing conformation 期刊论文
PNAS, 2018, 卷号: 115, 期号: 23, 页码: 5962–5967
作者:  Zhenning Ren;  Jumin Lee;  Mahdi Muhammad Moosa;  Yin Nian;  Liya Hu;  Zhichun Xu;  Jason G. McCoy;  Allan Chris M. Ferreon;  Wonpil Im;  Ming Zhou
Adobe PDF(1351Kb)  |  收藏  |  浏览/下载:1281/0  |  提交时间:2018/09/26
Bcmalt  Double-cysteine Cross-linking  Inward-facing Conformation  Single-molecule Fret  Elevator-type Mechanism Of Transport  
以离子通道为靶点的新型抗心律失常分子作用研究 学位论文
理学博士, 北京: 中国科学院大学, 2018
作者:  李欢
Adobe PDF(3747Kb)  |  收藏  |  浏览/下载:1251/0  |  提交时间:2019/09/05
心律失常,离子通道,心肌动作电位,动物模型,长qt间期综合征  Arrhymia, Ion Channels, actIon Potential, Animal Model, Long Qt Syndrome  
转铁蛋白(FPN)表达、纯化和功能的研究 学位论文
理学硕士, 北京: 中国科学院大学, 2018
作者:  许志纯
Adobe PDF(2993Kb)  |  收藏  |  浏览/下载:1282/1  |  提交时间:2019/09/02
转铁蛋白,点突变,转运活性,底物结合亲和力,结合位点  
Lycoplanine A, a C 16 N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum 期刊论文
Organic Letters, 2017, 卷号: **, 期号: **, 页码: published online
作者:  Zhang ZJ;  Nian Y;  Wu XD;  Yang J*;  Zhao QS*;  Zhu QF;  Li XN;  Su J;  qinshizhao@mail.kib.ac.cn
Adobe PDF(599Kb)  |  收藏  |  浏览/下载:1273/2  |  提交时间:2017/08/24
A clinical and mechanistic study of topical borneol-induced analgesia 期刊论文
EMBO Molecular Medicine, 2017, 卷号: **, 期号: **, 页码: Published online
作者:  Wang S*;  Zhang D;  Su DY;  Song HL;  Xu ZC;  Cui JM;  Zhou M;  Yang J*;  Hu JS;  Xiao JR*;  Jia Q;  Xu W;  wangshu@mail.kiz.ac.cn
Adobe PDF(1739Kb)  |  收藏  |  浏览/下载:1511/2  |  提交时间:2017/04/13
Trpm8  Borneol  Pain  Topical Analgesic  Traditional Chinese Medicine