Platypus and echidna genomes reveal mammalian biology and evolution

	Platypus and echidna genomes reveal mammalian biology and evolution
	Zhou, Y; Shearwin-Whyatt, L; Li, J; Song, ZZ; Hayakawa, T; Stevens, D; Fenelon, JC; Peel, E; Cheng, YY; Pajpach, F; Bradley, N; Suzuki, H; Nikaido, M; Damas, J; Daish, T; Perry, T; Zhu, ZX; Geng, YC; Rhie, A; Sims, Y; Wood, J; Haase, B; Mountcastle, J; Fedrigo, O; Li, QY; Yang, HM; Wang, J; Johnston, SD; Phillippy, AM; Howe, K; Jarvis, ED; Ryder, OA; Kaessmann, H; Donnelly, P; Korlach, J; Lewin, HA; Graves, J; Belov, K; Renfree, MB; Grutzner, F; Zhou, Q; Zhang, GJ
	2021
发表期刊	NATURE
ISSN	0028-0836
卷号	592 期号:7856 页码:756-+
摘要	Egg-laying mammals (monotremes) are the only extant mammalian outgroup to therians (marsupial and eutherian animals) and provide key insights into mammalian evolution(1,2). Here we generate and analyse reference genomes of the platypus (Ornithorhynchus anatinus) and echidna (Tachyglossus aculeatus), which represent the only two extant monotreme lineages. The nearly complete platypus genome assembly has anchored almost the entire genome onto chromosomes, markedly improving the genome continuity and gene annotation. Together with our echidna sequence, the genomes of the two species allow us to detect the ancestral and lineage-specific genomic changes that shape both monotreme and mammalian evolution. We provide evidence that the monotreme sex chromosome complex originated from an ancestral chromosome ring configuration. The formation of such a unique chromosome complex may have been facilitated by the unusually extensive interactions between the multi-X and multi-Y chromosomes that are shared by the autosomal homologues in humans. Further comparative genomic analyses unravel marked differences between monotremes and therians in haptoglobin genes, lactation genes and chemosensory receptor genes for smell and taste that underlie the ecological adaptation of monotremes.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13443
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Zhou, Y,Shearwin-Whyatt, L,Li, J,et al. Platypus and echidna genomes reveal mammalian biology and evolution[J]. NATURE,2021,592(7856):756-+.
APA	Zhou, Y.,Shearwin-Whyatt, L.,Li, J.,Song, ZZ.,Hayakawa, T.,...&Zhang, GJ.(2021).Platypus and echidna genomes reveal mammalian biology and evolution.NATURE,592(7856),756-+.
MLA	Zhou, Y,et al."Platypus and echidna genomes reveal mammalian biology and evolution".NATURE 592.7856(2021):756-+.

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