Integrating Genomic and Transcriptomic Data to Reveal Genetic Mechanisms Underlying Piao Chicken Rumpless Trait

	Integrating Genomic and Transcriptomic Data to Reveal Genetic Mechanisms Underlying Piao Chicken Rumpless Trait
	Wang, YM; Khederzadeh, S; Li, SR; Otecko, NO; Irwin, DM; Thakur, M; Ren, XD; Wang, MS; Wu, DD; Zhang, YP
	2021
发表期刊	GENOMICS PROTEOMICS & BIOINFORMATICS
ISSN	1672-0229
卷号	19 期号:5 页码:787-799
摘要	Piao chicken, a rare Chinese native poultry breed, lacks primary tail structures, such as pygostyle, caudal vertebra, uropygial gland, and tail feathers. So far, the molecular mechanisms underlying tail absence in this breed remain unclear. In this study, we comprehensively employed comparative transcriptomic and genomic analyses to unravel potential genetic underpinnings of rumplessness in Piao chicken. Our results reveal many biological factors involved in tail development and several genomic regions under strong positive selection in this breed. These regions contain candidate genes associated with rumplessness, including Irx4, Il18, Hspb2, and Cryab. Retrieval of quantitative trait loci (QTL) and gene functions implies that rumplessness might be consciously or unconsciously selected along with the high-yield traits in Piao chicken. We hypothesize that strong selection pressures on regulatory elements might lead to changes in gene activity in mesenchymal stem cells of the tail bud. The ectopic activity could eventually result in tail truncation by impeding differentiation and proliferation of the stem cells. Our study provides fundamental insights into early initiation and genetic basis of the rumpless phenotype in Piao chicken.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13555
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Wang, YM,Khederzadeh, S,Li, SR,et al. Integrating Genomic and Transcriptomic Data to Reveal Genetic Mechanisms Underlying Piao Chicken Rumpless Trait[J]. GENOMICS PROTEOMICS & BIOINFORMATICS,2021,19(5):787-799.
APA	Wang, YM.,Khederzadeh, S.,Li, SR.,Otecko, NO.,Irwin, DM.,...&Zhang, YP.(2021).Integrating Genomic and Transcriptomic Data to Reveal Genetic Mechanisms Underlying Piao Chicken Rumpless Trait.GENOMICS PROTEOMICS & BIOINFORMATICS,19(5),787-799.
MLA	Wang, YM,et al."Integrating Genomic and Transcriptomic Data to Reveal Genetic Mechanisms Underlying Piao Chicken Rumpless Trait".GENOMICS PROTEOMICS & BIOINFORMATICS 19.5(2021):787-799.

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2023041107.pdf（600KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文