Differential effects of social isolation on oligodendrocyte development in different brain regions: insights from a canine model

	Differential effects of social isolation on oligodendrocyte development in different brain regions: insights from a canine model
	Hong, HL; Guo, C; Liu, XR; Yang, LG; Ren, W; Zhao, H; Li, Y; Zhou, ZY; Lam, SM; Mi, JD; Zuo, ZT; Liu, CR; Wang, GD; Zhuo, Y; Zhang, YP; Li, YX; Shui, GH; Zhang, YQ; Xiong, Y
	2023
发表期刊	FRONTIERS IN CELLULAR NEUROSCIENCE
卷号	17
摘要	Social isolation (SI) exerts diverse adverse effects on brain structure and function in humans. To gain an insight into the mechanisms underlying these effects, we conducted a systematic analysis of multiple brain regions from socially isolated and group-housed dogs, whose brain and behavior are similar to humans. Our transcriptomic analysis revealed reduced expression of myelin-related genes specifically in the white matter of prefrontal cortex (PFC) after SI during the juvenile stage. Despite these gene expression changes, myelin fiber organization in PFC remained unchanged. Surprisingly, we observed more mature oligodendrocytes and thicker myelin bundles in the somatosensory parietal cortex in socially isolated dogs, which may be linked to an increased expression of ADORA2A, a gene known to promote oligodendrocyte maturation. Additionally, we found a reduced expression of blood-brain barrier (BBB) structural components Aquaporin-4, Occludin, and Claudin1 in both PFC and parietal cortices, indicating BBB disruption after SI. In agreement with BBB disruption, myelin-related sphingolipids were increased in cerebrospinal fluid in the socially isolated group. These unexpected findings show that SI induces distinct alterations in oligodendrocyte development and shared disruption in BBB integrity in different cortices, demonstrating the value of dogs as a complementary animal model to uncover molecular mechanisms underlying SI-induced brain dysfunction.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14077
专题	科研部门_行为遗传与进化（王国栋）
推荐引用方式 GB/T 7714	Hong, HL,Guo, C,Liu, XR,et al. Differential effects of social isolation on oligodendrocyte development in different brain regions: insights from a canine model[J]. FRONTIERS IN CELLULAR NEUROSCIENCE,2023,17.
APA	Hong, HL.,Guo, C.,Liu, XR.,Yang, LG.,Ren, W.,...&Xiong, Y.(2023).Differential effects of social isolation on oligodendrocyte development in different brain regions: insights from a canine model.FRONTIERS IN CELLULAR NEUROSCIENCE,17.
MLA	Hong, HL,et al."Differential effects of social isolation on oligodendrocyte development in different brain regions: insights from a canine model".FRONTIERS IN CELLULAR NEUROSCIENCE 17(2023).

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