| Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families | |
Yang Y1,2; Zhou TC1,3,4; Wang HW6; Irwin DM4,7; Zhang YP*1,3,4,5 ; Peng MS4,5; Liu YY2; Li YP2
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| 2016 | |
| 发表期刊 | MITOCHONDRIAL DNA
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| 卷号 | 27期号:3页码:2040-2044 |
| 摘要 | Previous work suggests that mitochondrial DNA (mtDNA) derived from the maternal genome has a close affinity with type 2 diabetes. This would support a familial pattern for type 2 diabetes. Thereby, we analyzed complete mtDNA genomes from two families, A and B, from Southwest China that demonstrated maternally inherited type 2 diabetes. Our data support that mtDNA lineages from families A and B belong to haplogroups A4 and D4h1, respectively. This suggests that maternally inherited type 2 diabetes with similar penetrances can arise in Chinese individuals with strikingly different maternal genetic backgrounds. Two private coding region mutations (G13759A in MT-ND5 and G15930A in tRNA-Thr) were identified in family B. Further evolutionary and phylogenetic analyses suggest that both these mutations have multiple origins and are unlikely to be disease causing. |
| 关键词 | Diabetes Haplogroup Mitochondrial Dna Multiple Origins Private Mutations |
| 资助者 | This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. ; This work was supported by grants from the National Natural Science Foundation of China (No. 81260135), the training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province (No. 2011CI045) and the fund of medical leader in Yunnan Province (No. D-201217). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to M. -S. P. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/10325 |
| 专题 | 科研部门_分子进化与基因组多样性（张亚平） 遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, Yunnan Province, China 2.Department of endocrinology, the Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan Province, , China 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China 5.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan Province, China 6.Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University, Yunnan Province, China 7.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada |
| 推荐引用方式 GB/T 7714 | Yang Y,Zhou TC,Wang HW,et al. Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families[J]. MITOCHONDRIAL DNA,2016,27(3):2040-2044. |
| APA | Yang Y.,Zhou TC.,Wang HW.,Irwin DM.,Zhang YP*.,...&Li YP.(2016).Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families.MITOCHONDRIAL DNA,27(3),2040-2044. |
| MLA | Yang Y,et al."Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families".MITOCHONDRIAL DNA 27.3(2016):2040-2044. |
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