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	Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents*
	Wang B1; Li J2; Zheng YT3; Huang WL*1; Zhang HB1; Qian H*1; ydhuangwenlong@126.com; qianhai24@163.com
	2011
发表期刊	CHINESE CHEMICAL LETTERS
卷号	22期号:7页码:781-784
合作性质	其它
摘要	A series of Andro derivatives were described and evaluated for their anti-HIV activity in vitro. Compound 10 and 16b, of which Ti were > 10, had some anti-HIV-1 activity in vitro. Therein, compound 10 which was the best potent compound, could serve as a new lead for further development of anti-AIDS agents. (C) 2011 Wen Long Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society.
关键词	Andrographolide Anti-hiv Derivatives Natural Products Synthesis
资助者	Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033).
收录类别	SCI
语种	英语
资助者	Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033). ; Thework was supported by the National Natural ScienceFundation ofChina (No. 30772647)and the special major science and technology project of ‘‘Creation of Major New Drugs’’ (No. 2009ZX09102-033).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/10418
专题	科研部门_分子免疫药理学（郑永唐） 科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	ydhuangwenlong@126.com; qianhai24@163.com
作者单位	1.Center of Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China 2.School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Wang B,Li J,Zheng YT,et al. Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents*[J]. CHINESE CHEMICAL LETTERS,2011,22(7):781-784.
APA	Wang B.,Li J.,Zheng YT.,Huang WL*.,Zhang HB.,...&qianhai24@163.com.(2011).Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents*.CHINESE CHEMICAL LETTERS,22(7),781-784.
MLA	Wang B,et al."Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents*".CHINESE CHEMICAL LETTERS 22.7(2011):781-784.

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2016083006.pdf（168KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

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