A nerve growth factor from the venom of Chinese cobra (Naja naja atra) and its effects on male reproductive system in rats

	A nerve growth factor from the venom of Chinese cobra (Naja naja atra) and its effects on male reproductive system in rats
	Xu TR; Wang WY; Lu QM; Xiong YL*; Huang YH; Meng QX; Li DS; xutr@163.net
	1999
发表期刊	COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY Part C
卷号	124 期号:2 页码:149-156
合作性质	其它
摘要	A nerve growth factor (NGF) was isolated from the venom of Chinese cobra (Naja naja ntr a) by ion exchange chromatography, gel filtration and fast protein liquid chromatography (FPLC). The N-terminal sequence of 22 amino acid residues was identical with other NGFs previously purified from the venom of the same genus. The NGF monomer molecular weight was estimated to be 13 500 by reducing SDS-PAGE and the isoelectric point was determined to be 7.2 by isoelectric focusing electrophoresis. NGF improved the epididymal sperm motility of male rats and increased the pregnancy rate and fetus number of mated female rats. The serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) of male rats administrated NGF + gossypol was lower than that of male rats administrated gossypol. Histological sections of testes and epididymides showed that NGF reduced the destructive effects of gossypol on rat testes.
关键词	Gossypol Hormone Isolation Naja Naja Atra Nerve Growth Factor Reproductive System Testes Venom
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/10666
专题	科研部门_天然药物功能蛋白质学科组（赖仞）其他
通讯作者	xutr@163.net
作者单位	Kunming Institute of Zoology, Chinese Academy of Sciences Kunming 650223 PR China
推荐引用方式 GB/T 7714	Xu TR,Wang WY,Lu QM,et al. A nerve growth factor from the venom of Chinese cobra (Naja naja atra) and its effects on male reproductive system in rats[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY Part C,1999,124(2):149-156.
APA	Xu TR.,Wang WY.,Lu QM.,Xiong YL*.,Huang YH.,...&xutr@163.net.(1999).A nerve growth factor from the venom of Chinese cobra (Naja naja atra) and its effects on male reproductive system in rats.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY Part C,124(2),149-156.
MLA	Xu TR,et al."A nerve growth factor from the venom of Chinese cobra (Naja naja atra) and its effects on male reproductive system in rats".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY Part C 124.2(1999):149-156.

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