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	Age-related effects of bromocriptine on sensory gating in rhesus monkeys
	Liu N1,3,4; Yu S2; Zhou YF2; Cai JX1,2; Ma YY*1,3; yuanma@hotmail.com
	2005
发表期刊	NEUROREPORT
卷号	16期号:6页码:603-606
摘要	Declines in dopamine neurotransmission are a robust characteristic of the process of normal aging. Using neuroimaging, biochemical and cognitive methods, age-related reduction of D2 receptor has been noted in a wide range of species. On the other hand, it is well known that dopamine plays a crucial role in the modulation of sensory gating. Here, we examined age-related alterations of D2 receptor in rhesus monkeys, using a sensory gating paradigm. The direct D2 receptor agonist, bromocriptine, was characterized in young adult and aged monkeys.We found bromocriptine disrupted sensory gating in young adult monkeys but not in aged ones. Our results provided new evidence that there is a functional decline of D2 receptor in aged monkeys.© 2005 Lippincott Williams & Wilkins.
关键词	Aging Dopamine Rhesus Monkeys Sensory Gating
资助者	Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu.
收录类别	SCI
语种	英语
资助者	Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. ; Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/10891
专题	认知障碍病理学 其他
通讯作者	yuanma@hotmail.com
作者单位	1.Kunming Institute of Zoology,Chinese Academyof Sciences,Kunming 650223,PRChina 2.Schoolof Life Sciences, UniversityofScience & TechnologyofChina,Hefei 230027 ,PRChina 3.Centerof Brain and Mind,Chinese Academyof Sciences, Beijing100080,PRChin 4.The Graduate Schoolof the Chinese Academyof Science, Beijing100039,PRChina
推荐引用方式 GB/T 7714	Liu N,Yu S,Zhou YF,et al. Age-related effects of bromocriptine on sensory gating in rhesus monkeys[J]. NEUROREPORT,2005,16(6):603-606.
APA	Liu N,Yu S,Zhou YF,Cai JX,Ma YY*,&yuanma@hotmail.com.(2005).Age-related effects of bromocriptine on sensory gating in rhesus monkeys.NEUROREPORT,16(6),603-606.
MLA	Liu N,et al."Age-related effects of bromocriptine on sensory gating in rhesus monkeys".NEUROREPORT 16.6(2005):603-606.

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