Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis

doi:10.1002/path.5153

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis
	Rong Liu 1,2; Peiguo Shi 1; Zhongmei Zhou 1; Hailin Zhang 1; Wei Li 3; Hong Zhang 4; Ceshi Chen 1
	2018
发表期刊	The Journal of pathology
期号	页码:
摘要	Krüpple-like factor 5 (KLF5) is required for the development of the embryo andmultiple organs, such as the lung and intestine. KLF5 plays a pro-proliferativeand oncogenic role in several carcinomas, including breast cancer. However, itsrole in normal mammary gland development and oncogenesis has not beenelucidated in vivo. In this study, we used mammary gland-specific Klf5conditional knockout mice derived by mating Klf5-LoxP and MMTV-Cre mice.The genetic ablation of Klf5 suppresses mammary gland ductal elongation andlobuloalveolar formation. Klf5 deficiency inhibits mammary epithelial cellproliferation, survival, and stem cell maintenance. Klf5 promotes mammarystemness, at least partially, by directly promoting the transcription of Slug. Finally,Klf5 depletion suppressed PyMT-induced mammary gland tumor cell stemness,tumor initiation and growth in vivo. Slug also mediated these functions of Klf5 invivo.
关键词	Klf5 Slug Mammary Gland Development Mammary Stem Cell Breast Cancer
DOI	10.1002/path.5153
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12299
专题	科研部门_肿瘤生物学（陈策实）
通讯作者	Rong Liu; Ceshi Chen
作者单位	1.Kunming Institute of Zoology, Chinese Academy of Sciences, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming 650223, China 2.Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China 3.Department of Urology, First People's Hospital of Yunnan Province, Kunming 650032, China 4.Department of Nuclear Medicine, Second Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
推荐引用方式 GB/T 7714	Rong Liu,Peiguo Shi,Zhongmei Zhou,et al. Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis[J]. The Journal of pathology,2018():.
APA	Rong Liu.,Peiguo Shi.,Zhongmei Zhou.,Hailin Zhang.,Wei Li.,...&Ceshi Chen.(2018).Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis.The Journal of pathology(),.
MLA	Rong Liu,et al."Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis".The Journal of pathology .(2018):.

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