Origin of new genes after zygotic genome activation in vertebrate

doi:10.1093/jmcb/mjx057

	Origin of new genes after zygotic genome activation in vertebrate
	Hai-Bo Xu 1,2; Dong-Dong Wu 1,3; Yan Li 4; Newton O. Otecko 1,3; Ya-Ping Zhang1,3,4 ; Bingyu Mao1,3
	2018
发表期刊	Journal of Molecular Cell Biology
卷号	10 期号:2 页码:139–146
摘要	New genes are drivers of evolutionary innovation and phenotypic evolution. Expression of new genes in early development raisesthe possibility that new genes could originate and be recruited for functions in embryonic development, but this remains undocu-mented. Here, based on temporal gene expression at different developmental stages in Xenopus tropicalis, we found that youngprotein-coding genes were significantly enriched for expression in developmental stages occurring after the midblastula trans-ition (MBT), and displayed a decreasing trend in abundance in the subsequent stages after MBT. To complement the finding, wedemonstrate essential functional attributes of a young orphan gene, named as Fog2, in morphological development. Our dataindicate that new genes could originate after MBT and be recruited for functions in embryonic development, and thus provideinsights for better understanding of the origin, evolution, and function of new genes.
关键词	Young Gene Evolution Zygotic Genome Activation New Gene Origin
DOI	10.1093/jmcb/mjx057
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12366
专题	科研部门_进化与发育转录组学（吴东东）科研部门_分子进化与基因组多样性（张亚平）
通讯作者	Bingyu Mao
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.College of Life Science, Anhui University, Hefei, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 4.State Key Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China
推荐引用方式 GB/T 7714	Hai-Bo Xu,Dong-Dong Wu,Yan Li,et al. Origin of new genes after zygotic genome activation in vertebrate[J]. Journal of Molecular Cell Biology,2018,10(2):139–146.
APA	Hai-Bo Xu,Dong-Dong Wu,Yan Li,Newton O. Otecko,Ya-Ping Zhang,&Bingyu Mao.(2018).Origin of new genes after zygotic genome activation in vertebrate.Journal of Molecular Cell Biology,10(2),139–146.
MLA	Hai-Bo Xu,et al."Origin of new genes after zygotic genome activation in vertebrate".Journal of Molecular Cell Biology 10.2(2018):139–146.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
179.pdf（931KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文