The lactase persistence allele -22018 G/A associated with body mass index in an Asian population

	The lactase persistence allele -22018 G/A associated with body mass index in an Asian population
	Charati, Hadi; Ori, Roghayeh Jabbari; Aghajanpour-Mir, Mohsen; Esmailizadeh, Ali; Zhang, Ya-Ping
	2020
发表期刊	Gene Reports
卷号	19 页码:Article No.: 100621
摘要	Background: A strong association of the -13910 C/T polymorphism with body mass index (BMI) and obesity has been previously reported in Europeans and Chilean goat herders. We aimed to examine the relationship of lactase persistence allele -22018 G/A with BMI and clinical characteristics in an Asian populations.Methods: We collected 400 samples from seven Iranian ethnic groups, from whom we investigated their lactose tolerance and screened the genetic variants in their lactase gene locus. Height, weight and clinical characteristics were directly measured. WHO classification of BMI was used.Results: The results indicated that Increasing BMI increased significantly the risk of blood pressure and fasting glucose and decreased body temperature in the studied population. We showed that the -22018 G/A allele was positively associated with BMI in Iranian and Asian populations (P < 0.05).Conclusion: In conclusion, in Asian population-based 7 major Iranian populations, we found evidence for association of the lactase persistence allele -22018*A with BMI and weight. In the future, meta-analysis of genome-wide association (GWA) studies with larger sample sizes are warranted to confirm our finding.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12704
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Charati, Hadi,Ori, Roghayeh Jabbari,Aghajanpour-Mir, Mohsen,et al. The lactase persistence allele -22018 G/A associated with body mass index in an Asian population[J]. Gene Reports,2020,19:Article No.: 100621.
APA	Charati, Hadi,Ori, Roghayeh Jabbari,Aghajanpour-Mir, Mohsen,Esmailizadeh, Ali,&Zhang, Ya-Ping.(2020).The lactase persistence allele -22018 G/A associated with body mass index in an Asian population.Gene Reports,19,Article No.: 100621.
MLA	Charati, Hadi,et al."The lactase persistence allele -22018 G/A associated with body mass index in an Asian population".Gene Reports 19(2020):Article No.: 100621.

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