Genomic regions under selection in the feralization of the dingoes

	Genomic regions under selection in the feralization of the dingoes
	Zhang, Shao-jie; Wang, Guo-Dong; Ma, Pengcheng; Zhang, Liang-liang; Yin, Ting-Ting; Liu, Yan-hu; Otecko, Newton O.; Wang, Meng; Ma, Ya-ping; Wang, Lu; Mao, Bingyu; Savolainen, Peter; Zhang, Ya-ping
	2020
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	11 期号:1
摘要	Dingoes are wild canids living in Australia, originating from domestic dogs. They have lived isolated from both the wild and the domestic ancestor, making them a unique model for studying feralization. Here, we sequence the genomes of 10 dingoes and 2 New Guinea Singing Dogs. Phylogenetic and demographic analyses show that dingoes originate from dogs in southern East Asia, which migrated via Island Southeast Asia to reach Australia around 8300 years ago, and subsequently diverged into a genetically distinct population. Selection analysis identifies 50 positively selected genes enriched in digestion and metabolism, indicating a diet change during feralization of dingoes. Thirteen of these genes have shifted allele frequencies compared to dogs but not compared to wolves. Functional assays show that an A-to-G mutation in ARHGEF7 decreases the endogenous expression, suggesting behavioral adaptations related to the transitions in environment. Our results indicate that the feralization of the dingo induced positive selection on genomic regions correlated to neurodevelopment, metabolism and reproduction, in adaptation to a wild environment.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12706
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Zhang, Shao-jie,Wang, Guo-Dong,Ma, Pengcheng,et al. Genomic regions under selection in the feralization of the dingoes[J]. NATURE COMMUNICATIONS,2020,11(1).
APA	Zhang, Shao-jie.,Wang, Guo-Dong.,Ma, Pengcheng.,Zhang, Liang-liang.,Yin, Ting-Ting.,...&Zhang, Ya-ping.(2020).Genomic regions under selection in the feralization of the dingoes.NATURE COMMUNICATIONS,11(1).
MLA	Zhang, Shao-jie,et al."Genomic regions under selection in the feralization of the dingoes".NATURE COMMUNICATIONS 11.1(2020).

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2021110103.pdf（1033KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文