Hematologic and spirometric characteristics of Tajik and Kyrgyz highlanders in the Pamir Mountains

	Hematologic and spirometric characteristics of Tajik and Kyrgyz highlanders in the Pamir Mountains
	Sulaiman, Xierzhatijiang; Xu, Wei-fang; Cai, Liu-Hong; Huang, Xiao-Yang; Cheng, Lu-Feng; Zhang, Ya-Ping
	2021
发表期刊	AMERICAN JOURNAL OF HUMAN BIOLOGY
ISSN	1042-0533
卷号	33 期号:2
摘要	Objectives In this study, we measured the hematologic and spirometric parameters of native Tajik and Kyrgyz highlanders in the Pamir Mountains to investigate adaptations to high altitude stressors. Methods Hematological parameters including arterial oxygen saturation (SaO(2)), red blood cell (RBC) counts, and hemoglobin (Hb) concentration were measured on Sarikoli Tajik (n = 80; 3100 m), Wakhi Tajik (n = 48; 3500 m), and Kyrgyz (n = 64; 3250 m) in comparison to lowland Uyghurs (n = 50; 1300 m). Spirometric parameters including forced vital capacity (FVC), the first second of forced expiration (FEV1), and forced expiratory flow between 25% and 75% (FEF25-75) were measured. We also reported mountain sickness symptoms in these highlanders and conducted a multivariate regression analysis to analyze the association between these symptoms and the measured parameters. Results SaO(2)of Sarikoli Tajik, Wakhi Tajik, and Kyrgyz (91%-93.5%) are significantly lower than lowland Uyghurs, yet are comparable to other native highlanders at a similar altitude. RBC counts and Hb concentrations of all three highland populations are significantly increased compared to Uyghurs. FVC is lower in Sarikoli Tajik, Wakhi Tajik, and Kyrgyz (male: 3.48-3.86 L, female: 2.47-2.78 L) compared to Uyghurs. Combined with normal FEV1, elevated FEV1/FVC ratio, and FEF25-75, the spirometric patterns of these highlanders indicate restrictive lung disease. A high prevalence of mountain sickness symptoms such as headache and nausea was found in all three highland populations, and are attributed to low FVC and aging by regression analysis. Conclusion Tajik and Kyrgyz highlanders showed adaptation in SaO(2), RBC, and Hb level, but poor performance in spirometry, which causes mountain sickness.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12710
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Sulaiman, Xierzhatijiang,Xu, Wei-fang,Cai, Liu-Hong,et al. Hematologic and spirometric characteristics of Tajik and Kyrgyz highlanders in the Pamir Mountains[J]. AMERICAN JOURNAL OF HUMAN BIOLOGY,2021,33(2).
APA	Sulaiman, Xierzhatijiang,Xu, Wei-fang,Cai, Liu-Hong,Huang, Xiao-Yang,Cheng, Lu-Feng,&Zhang, Ya-Ping.(2021).Hematologic and spirometric characteristics of Tajik and Kyrgyz highlanders in the Pamir Mountains.AMERICAN JOURNAL OF HUMAN BIOLOGY,33(2).
MLA	Sulaiman, Xierzhatijiang,et al."Hematologic and spirometric characteristics of Tajik and Kyrgyz highlanders in the Pamir Mountains".AMERICAN JOURNAL OF HUMAN BIOLOGY 33.2(2021).

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