Cationic Pillar[6]arene Induces Cell Apoptosis by Inhibiting Protein Tyrosine Phosphorylation Via Host-Guest Recognition

	Cationic Pillar[6]arene Induces Cell Apoptosis by Inhibiting Protein Tyrosine Phosphorylation Via Host-Guest Recognition
	Li, Can-Peng; Lu, Yu-Xun; Zi, Cheng-Ting; Zhao, Yu-Ting; Zhao, Hui; Zhang, Ya-Ping
	2020
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号	21 期号:14
摘要	We reported for the first time that cationic pillar[6]arene (cPA6) could tightly bind to peptide polymer (MW similar to 20-50 kDa), an artificial substrate for tyrosine (Tyr) phosphorylation, and efficiently inhibit Tyr protein phosphorylation through host-guest recognition. We synthesized a nanocomposite of black phosphorus nanosheets loaded with cPA6 (BPNS@cPA6) to explore the effect of cPA6 on cells. BPNS@cPA6 was able to enter HepG2 cells, induced apoptosis, and inhibited cell proliferation by reducing the level of Tyr phosphorylation. Furthermore, BPNS@cPA6 showed a stronger ability of inhibiting cell proliferation in tumor cells than in normal cells. Our results revealed the supramolecular modulation of enzymatic Tyr phosphorylation by the host-guest recognition of cPA6.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12711
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Li, Can-Peng,Lu, Yu-Xun,Zi, Cheng-Ting,et al. Cationic Pillar[6]arene Induces Cell Apoptosis by Inhibiting Protein Tyrosine Phosphorylation Via Host-Guest Recognition[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(14).
APA	Li, Can-Peng,Lu, Yu-Xun,Zi, Cheng-Ting,Zhao, Yu-Ting,Zhao, Hui,&Zhang, Ya-Ping.(2020).Cationic Pillar[6]arene Induces Cell Apoptosis by Inhibiting Protein Tyrosine Phosphorylation Via Host-Guest Recognition.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(14).
MLA	Li, Can-Peng,et al."Cationic Pillar[6]arene Induces Cell Apoptosis by Inhibiting Protein Tyrosine Phosphorylation Via Host-Guest Recognition".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.14(2020).

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