Ambient Temperature is A Strong Selective Factor Influencing Human Development and Immunity

	Ambient Temperature is A Strong Selective Factor Influencing Human Development and Immunity
	Ji, Lindan; Wu, Dongdong; Xie, Haibing; Yao, Binbin; Chen, Yanming; Irwin, David M.; Huang, Dan; Xu, Jin; Tang, Nelson L. S.; Zhang, Yaping
	2020
发表期刊	GENOMICS PROTEOMICS & BIOINFORMATICS
ISSN	1672-0229
卷号	18 期号:5 页码:489-500
摘要	Solar energy, which is essential for the origin and evolution of all life forms on Earth, can be objectively recorded through attributes such as climatic ambient temperature (CAT), ultraviolet radiation (UVR), and sunlight duration (SD). These attributes have specific geographical variations and may cause different adaptation traits. However, the adaptation profile of each attribute and the selective role of solar energy as a whole during human evolution remain elusive. Here, we performed a genome-wide adaptation study with respect to CAT, UVR, and SD using the Human Genome Diversity Project-Centre Etude Polymorphism Humain (HGDP-CEPH) panel data. We singled out CAT as the most important driving force with the highest number of adaptive loci (6 SNPs at the genome-wide 1 x 10(-7) level; 401 at the suggestive 1 x 10(-5) level). Five of the six genome-wide significant adaptation SNPs were successfully replicated in an independent Chinese population (N = 1395). The corresponding 316 CAT adaptation genes were mostly involved in development and immunity. In addition, 265 (84%) genes were related to at least one genome-wide association study (GWAS)-mapped human trait, being significantly enriched in anthropometric loci such as those associated with body mass index (chi(2); P < 0.005), immunity, metabolic syndrome, and cancer (chi(2); P < 0.05). For these adaptive SNPs, balancing selection was evident in Euro-Asians, whereas obvious positive and/or purifying selection was observed in Africans. Taken together, our study indicates that CAT is the most important attribute of solar energy that has driven genetic adaptation in development and immunity among global human populations. It also supports the non-neutral hypothesis for the origin of disease-predisposition alleles in common diseases.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12714
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Ji, Lindan,Wu, Dongdong,Xie, Haibing,et al. Ambient Temperature is A Strong Selective Factor Influencing Human Development and Immunity[J]. GENOMICS PROTEOMICS & BIOINFORMATICS,2020,18(5):489-500.
APA	Ji, Lindan.,Wu, Dongdong.,Xie, Haibing.,Yao, Binbin.,Chen, Yanming.,...&Zhang, Yaping.(2020).Ambient Temperature is A Strong Selective Factor Influencing Human Development and Immunity.GENOMICS PROTEOMICS & BIOINFORMATICS,18(5),489-500.
MLA	Ji, Lindan,et al."Ambient Temperature is A Strong Selective Factor Influencing Human Development and Immunity".GENOMICS PROTEOMICS & BIOINFORMATICS 18.5(2020):489-500.

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