Comparative population genomic analysis uncovers novel genomic footprints and genes associated with small body size in Chinese pony

	Comparative population genomic analysis uncovers novel genomic footprints and genes associated with small body size in Chinese pony
	Nanaei, Hojjat Asadollahpour; Esmailizadeh, Ali; Mehrgardi, Ahmad Ayatollahi; Han, Jianlin; Wu, Dong-Dong; Li, Yan; Zhang, Ya-Ping
	2020
发表期刊	BMC GENOMICS
ISSN	1471-2164
卷号	21 期号:1
摘要	BackgroundBody size is considered as one of the most fundamental properties of an organism. Due to intensive breeding and artificial selection throughout the domestication history, horses exhibit striking variations for heights at withers and body sizes. Debao pony (DBP), a famous Chinese horse, is known for its small body size and lives in Guangxi mountains of southern China. In this study, we employed comparative population genomics to study the genetic basis underlying the small body size of DBP breed based on the whole genome sequencing data. To detect genomic signatures of positive selection, we applied three methods based on population comparison, fixation index (F-ST), cross population composite likelihood ratio (XP-CLR) and nucleotide diversity (theta), and further analyzed the results to find genomic regions under selection for body size-related traits.ResultsA number of protein-coding genes in windows with the top 1% values of F-ST (367 genes), XP-CLR (681 genes), and log(2) (theta pi ratio) (332 genes) were identified. The most significant signal of positive selection was mapped to the NELL1 gene, probably underlies the body size and development traits, and may also have been selected for short stature in the DBP population. In addition, some other loci on different chromosomes were identified to be potentially involved in the development of body size.Conclusions p id=Par Results of our study identified some positively selected genes across the horse genome, which are possibly involved in body size traits. These novel candidate genes may be useful targets for clarifying our understanding of the molecular basis of body size and as such they should be of great interest for future research into the genetic architecture of relevant traits in horse breeding program.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12718
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Nanaei, Hojjat Asadollahpour,Esmailizadeh, Ali,Mehrgardi, Ahmad Ayatollahi,et al. Comparative population genomic analysis uncovers novel genomic footprints and genes associated with small body size in Chinese pony[J]. BMC GENOMICS,2020,21(1).
APA	Nanaei, Hojjat Asadollahpour.,Esmailizadeh, Ali.,Mehrgardi, Ahmad Ayatollahi.,Han, Jianlin.,Wu, Dong-Dong.,...&Zhang, Ya-Ping.(2020).Comparative population genomic analysis uncovers novel genomic footprints and genes associated with small body size in Chinese pony.BMC GENOMICS,21(1).
MLA	Nanaei, Hojjat Asadollahpour,et al."Comparative population genomic analysis uncovers novel genomic footprints and genes associated with small body size in Chinese pony".BMC GENOMICS 21.1(2020).

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