Donkey genomes provide new insights into domestication and selection for coat color

	Donkey genomes provide new insights into domestication and selection for coat color
	Wang, Changfa; Li, Haijing; Guo, Yu; Huang, Jinming; Sun, Yan; Min, Jiumeng; Wang, Jinpeng; Fang, Xiaodong; Zhao, Zicheng; Wang, Shuai; Zhang, Yanlin; Liu, Qingfeng; Jiang, Qiang; Wang, Xiuge; Guo, Yijun; Yang, Chunhong; Wang, Yinchao; Tian, Fang; Zhuang, Guilong; Fan, Yanna; Gao, Qican; Li, Yuhua; Ju, Zhihua; Li, Jianbin; Li, Rongling; Hou, Minghai; Yang, Guiwen; Liu, Guiqin; Liu, Wenqiang; Guo, Jiao; Pan, Shanshan; Fan, Guangyi; Zhang, Wei; Zhang, Ruitao; Yu, Jie; Zhang, Xinhao; Yin, Qi; Ji, Chuanliang; Jin, Yuanchun; Yue, Guidong; Liu, Mei; Xu, Jiake; Liu, Shimin; Jordana, Jordi; Noce, Antonia; Amills, Marcel; Wu, Dong Dong; Li, Shuaicheng; Zhou, Xiangshan; Zhong, Jifeng
	2020
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	11 期号:1
摘要	Current knowledge about the evolutionary history of donkeys is still incomplete due to the lack of archeological and whole-genome diversity data. To fill this gap, we have de novo assembled a chromosome-level reference genome of one male Dezhou donkey and analyzed the genomes of 126 domestic donkeys and seven wild asses. Population genomics analyses indicate that donkeys were domesticated in Africa and conclusively show reduced levels of Y chromosome variability and discordant paternal and maternal histories, possibly reflecting the consequences of reproductive management. We also investigate the genetic basis of coat color. While wild asses show diluted gray pigmentation (Dun phenotype), domestic donkeys display non-diluted black or chestnut coat colors (non-Dun) that were probably established during domestication. Here, we show that the non-Dun phenotype is caused by a 1bp deletion downstream of the TBX3 gene, which decreases the expression of this gene and its inhibitory effect on pigment deposition. A new donkey reference genome and comparisons with wild asses yields insights into the evolutionary history of donkey domestication and identifies a genetic variant that results in the non-Dun coat colours of domestic donkeys.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12797
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Wang, Changfa,Li, Haijing,Guo, Yu,et al. Donkey genomes provide new insights into domestication and selection for coat color[J]. NATURE COMMUNICATIONS,2020,11(1).
APA	Wang, Changfa.,Li, Haijing.,Guo, Yu.,Huang, Jinming.,Sun, Yan.,...&Zhong, Jifeng.(2020).Donkey genomes provide new insights into domestication and selection for coat color.NATURE COMMUNICATIONS,11(1).
MLA	Wang, Changfa,et al."Donkey genomes provide new insights into domestication and selection for coat color".NATURE COMMUNICATIONS 11.1(2020).

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