| Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance | |
| Jiang, Jian-Jun; Kong, Qing-Peng | |
| 2020 | |
| 发表期刊 | RNA BIOLOGY
 |
| ISSN | 1547-6286 |
| 卷号 | 17期号:11页码:1657-1665 |
| 摘要 | Mouse and rats are staple model organisms that have been traditionally used for oncological studies; however, their short lifespan and highly prone to cancers limit their utilizationsin understanding the mechanisms of cancer resistance. In recent years, several studies of the non-standard long-lived mammalian species like naked mole rat (NMR) have provided new insights of mechanisms in natural anti-cancer. How long-lived species genetically maintain longevity and cancer-resistance remains largely elusive. To better understand the underlying anti-cancer mechanisms in long-lived mammals, we genome widely identified long noncoding RNA (lncRNA) transcripts of two longevous mammals, bowhead whale (BW,Balaena mysticetus) and Brandt's bat (BB,Myotis brandtii) and featured their sequence traits, expression patterns, and their correlations with cancer-resistance. Similar with naked mole rat (NMR,Heterocephalus glaber), the most long-lived rodent, BW and BB lncRNAs show low sequence conservation and dynamic expressions among tissues and physiological stages. By utilizing k-mers clustering, 75-136 of BW, BB and NMR lncRNAs were found in close relation (Pearson'sr >= 0.9, p < 0.01) with human ageing diseases related lncRNAs (HAR-Lncs). In addition, we observed thousands of BB and BW lncRNAs strongly co-expressed (r> 0.8 orr<-0.8, p < 0.01) with potential tumour suppressors, indicating that lncRNAs are potentially involved in anti-cancer regulation in long-lived mammals. Our study provides the basis for lncRNA researches in perspectives of evolution and anti-cancer studies. |
| 收录类别 | sci |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12898 |
| 专题 | 科研部门_分子人类学（孔庆鹏） |
| 推荐引用方式 GB/T 7714 | Jiang, Jian-Jun,Kong, Qing-Peng. Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance[J]. RNA BIOLOGY,2020,17(11):1657-1665. |
| APA | Jiang, Jian-Jun,&Kong, Qing-Peng.(2020).Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance.RNA BIOLOGY,17(11),1657-1665. |
| MLA | Jiang, Jian-Jun,et al."Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance".RNA BIOLOGY 17.11(2020):1657-1665. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2021110102.pdf（2391KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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