Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments

	Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments
	Liu, Qingyun; Wei, Jianhao; Li, Yawei; Wang, Mei; Su, Jun; Lu, Yonghui; Lopez, Mariana G.; Qian, Xueqin; Zhu, Zhaoqin; Wang, Haiying; Gan, Mingyun; Jiang, Qi; Fu, Yun-Xin; Takiff, Howard; Comas, Inaki; Li, Feng; Lu, Xuemei; Fortune, Sarah M.; Gao, Qian
	2020
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	6 期号:22
摘要	Mycobacterium tuberculosis (Mtb) infection results in a spectrum of clinical and histopathologic manifestations. It has been proposed that the environmental and immune pressures associated with different contexts of infection have different consequences for the associated bacterial populations, affecting drug susceptibility and the emergence of resistance. However, there is little concrete evidence for this model. We prospectively collected sputum samples from 18 newly diagnosed and treatment-naive patients with tuberculosis and sequenced 795 colony-derived Mtb isolates. Mutant accumulation rates varied considerably between different bacilli isolated from the same individual, and where high rates of mutation were observed, the mutational spectrum was consistent with reactive oxygen species-induced mutagenesis. Elevated bacterial mutation rates were identified in isolates from HIV-negative but not HIV-positive individuals, suggesting that they were immune-driven. These results support the model that mutagenesis of Mtb in vivo is modulated by the host environment, which could drive the emergence of variants associated with drug resistance in a host-dependent manner.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12959
专题	科研部门_适应性进化与进化医学（吕雪梅）昆明动物研究所
推荐引用方式 GB/T 7714	Liu, Qingyun,Wei, Jianhao,Li, Yawei,et al. Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments[J]. SCIENCE ADVANCES,2020,6(22).
APA	Liu, Qingyun.,Wei, Jianhao.,Li, Yawei.,Wang, Mei.,Su, Jun.,...&Gao, Qian.(2020).Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments.SCIENCE ADVANCES,6(22).
MLA	Liu, Qingyun,et al."Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments".SCIENCE ADVANCES 6.22(2020).

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