USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5

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	USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5
	Wu, YY; Qin, JY; Li, FB; Yang, CY; Li, Z; Zhou, ZM; Zhang, HL; Lie, YX; Wang, XY; Liu, R; Tao, Q; Chen, WL; Chen, CS
	2019
发表期刊	JOURNAL OF BIOLOGICAL CHEMISTRY
ISSN	0021-9258
卷号	294 期号:47 页码:17837-17847
摘要	The Kr?ppel-like factor 5 (KLF5) transcription factor is highly expressed in basal type breast cancer and promotes breast cancer cell proliferation, survival, migration, and tumorigenesis. KLF5 protein stability is regulated by ubiquitination. In this study, ubiquitin-specific protease 3 (USP3) was identified as a new KLF5 deubiquitinase by genome-wide siRNA library screening. We demonstrated that USP3 interacts with KLF5 and stabilizes KLF5 via deubiquitination. USP3 knockdown inhibits breast cancer cell proliferation in vitro and tumorigenesis in vivo, which can be partially rescued by ectopic expression of KLF5. Furthermore, we observed a positive correlation between USP3 and KLF5 protein expression levels in human breast cancer samples. These findings suggest that USP3 is a new KLF5 deubiquitinase and that USP3 may represent a potential therapeutic target for breast cancer.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12984
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Wu, YY,Qin, JY,Li, FB,et al. USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2019,294(47):17837-17847.
APA	Wu, YY.,Qin, JY.,Li, FB.,Yang, CY.,Li, Z.,...&Chen, CS.(2019).USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5.JOURNAL OF BIOLOGICAL CHEMISTRY,294(47),17837-17847.
MLA	Wu, YY,et al."USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5".JOURNAL OF BIOLOGICAL CHEMISTRY 294.47(2019):17837-17847.

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2020110410.pdf（1579KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文