Efficient assembly and long-term stability of defensive microbiomes via private resources and community bistability

	Efficient assembly and long-term stability of defensive microbiomes via private resources and community bistability
	Boza, G; Worsley, SF; Yu, DW; Scheuring, I
	2019
发表期刊	PLOS COMPUTATIONAL BIOLOGY
ISSN	1553-734X
卷号	15 期号:5 页码:-
摘要	Understanding the mechanisms that promote the assembly and maintenance of host-beneficial microbiomes is an open problem. Empirical evidence supports the idea that animal and plant hosts can combine private resources' with the ecological phenomenon known as community bistability' to favour some microbial strains over others. We briefly review evidence showing that hosts can: (i) protect the growth of beneficial strains in an isolated habitat, (ii) use antibiotics to suppress non-beneficial, competitor strains, and (iii) provide resources that only beneficial strains are able to translate into an increased rate of growth, reproduction, or antibiotic production. We then demonstrate in a spatially explicit, individual-based model that these three mechanisms act similarly by selectively promoting the initial proliferation of preferred strains, that is, by acting as a private resource. The faster early growth of preferred strains, combined with the phenomenon of community bistability,' allows those strains to continue to dominate the microbiome even after the private resource is withdrawn or made public. This is because after a beneficial colony reaches a sufficiently large size, it can resist invasion by parasites without further private support from the host. We further explicitly model localized microbial interactions and diffusion dynamics, and we show that an intermediate level of antibiotic diffusion is the most efficient mechanism in promoting preferred strains and that there is a wide range of parameters under which hosts can promote the assembly of a self-sustaining defensive microbiome. This in turn supports the idea that hosts readily evolve to promote host-beneficial defensive microbiomes. Author summary Host-associated microbiomes are complex communities, harbouring a great diversity of beneficial, neutral, or harmful species. Microbiome composition can have a significant effect on the health status and fitness of the host, and thus host species are selected to evolve mechanisms that favour the assembly of certain kinds of microbiomes over others. As we demonstrate, both by reviewing the literature and by using a detailed, spatially explicit, mathematical model, a host species can employ several cost-effective mechanisms to promote the establishment of beneficial bacteria, for example antibiotic producers, and to prevent the invasion of harmful microbes. These mechanisms include the host providing private resources in the form of a food source or inhabitable space that the preferred antibiotic-producing species are able to use to their advantage against species that are harmful to the host. After an antibiotic-producing species establishes itself with the help of the host, its colony is now self-sustaining, even if host resources now become publicly available, and can provide a reliable safeguard against parasites.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12991
专题	科研部门_生态学与环境保护中心（俞维理）
推荐引用方式 GB/T 7714	Boza, G,Worsley, SF,Yu, DW,et al. Efficient assembly and long-term stability of defensive microbiomes via private resources and community bistability[J]. PLOS COMPUTATIONAL BIOLOGY,2019,15(5):-.
APA	Boza, G,Worsley, SF,Yu, DW,&Scheuring, I.(2019).Efficient assembly and long-term stability of defensive microbiomes via private resources and community bistability.PLOS COMPUTATIONAL BIOLOGY,15(5),-.
MLA	Boza, G,et al."Efficient assembly and long-term stability of defensive microbiomes via private resources and community bistability".PLOS COMPUTATIONAL BIOLOGY 15.5(2019):-.

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