The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population

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	The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population
	Liu, WP; Yan, H; Zhou, DY; Cai, X; Zhang, YY; Li, SY; Li, HJ; Li, SW; Zhou, DS; Li, XX; Zhang, C; Sun, Y; Dai, JP; Zhong, JM; Yao, YG; Luo, XJ; Fang, YR; Zhang, D; Ma, YN; Yue, WH; Li, M; Xiao, X
	2019
发表期刊	TRANSLATIONAL PSYCHIATRY
ISSN	2158-3188
卷号	9 页码:-
摘要	Major depressive disorder (MDD) is recognized as a primary cause of disability worldwide, and effective management of this illness has been a great challenge. While genetic component is supposed to play pivotal roles in MDD pathogenesis, the genetic and phenotypic heterogeneity of the illness has hampered the discovery of its genetic determinants. In this study, in an independent Han Chinese sample (1824 MDD cases and 3031 controls), we conducted replication analyses of two genetic loci highlighted in a previous Chinese MDD genome-wide association study (GWAS), and confirmed the significant association of a single nucleotide polymorphism (SNP) rs12415800 near SIRT1. Subsequently, using hypothesis-free whole-brain analysis in two independent Han Chinese imaging samples, we found that individuals carrying the MDD risk allele of rs12415800 exhibited aberrant gray matter volume in the left posterior cerebellar lobe compared with those carrying the non-risk allele. Besides, in independent Han Chinese postmortem brain and peripheral blood samples, the MDD risk allele of rs12415800 predicted lower SIRT1 mRNA levels, which was consistent with the reduced expression of this gene in MDD patients compared with healthy subjects. These results provide further evidence for the involvement of SIRT1 in MDD, and suggest that this gene might participate in the illness via affecting the development of cerebellum, a brain region that is potentially underestimated in previous MDD studies.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13040
专题	科研部门_转化基因组（李明）
推荐引用方式 GB/T 7714	Liu, WP,Yan, H,Zhou, DY,et al. The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population[J]. TRANSLATIONAL PSYCHIATRY,2019,9:-.
APA	Liu, WP.,Yan, H.,Zhou, DY.,Cai, X.,Zhang, YY.,...&Xiao, X.(2019).The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population.TRANSLATIONAL PSYCHIATRY,9,-.
MLA	Liu, WP,et al."The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population".TRANSLATIONAL PSYCHIATRY 9(2019):-.

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