Population Genomics Analysis Revealed Origin and High-altitude Adaptation of Tibetan Pigs

	Population Genomics Analysis Revealed Origin and High-altitude Adaptation of Tibetan Pigs
	Ma, YF; Han, XM; Huang, CP; Zhong, L; Adeola, AC; Irwin, DM; Xie, HB; Zhang, YP
	2019
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	9 页码:-
摘要	Tibetan pig is native to the Qinghai-Tibet Plateau and has adapted to the high-altitude environmental condition such as hypoxia. However, its origin and genetic mechanisms underlying high-altitude adaptation still remain controversial and enigmatic. Herein, we analyze 229 genomes of wild and domestic pigs from Eurasia, including 63 Tibetan pigs, and detect 49.6 million high-quality variants. Phylogenomic and structure analyses show that Tibetan pigs have a close relationship with low-land domestic pigs in China, implying a common domestication origin. Positively selected genes in Tibetan pigs involved in high-altitude physiology, such as hypoxia, cardiovascular systems, UV damage, DNA repair. Three of loci with strong signals of selection are associated with EPAS1, CYP4F2, and THSD7A genes, related to hypoxia and circulation. We validated four non-coding mutations nearby EPAS1 and CYP4F2 showing reduced transcriptional activity in Tibetan pigs. A high-frequency missense mutation is found in THSD7A (Lys561Arg) in Tibetan pigs. The selective sweeps in Tibetan pigs was found in association with selection against non-coding variants, indicating an important role of regulatory mutations in Tibetan pig evolution. This study is important in understanding the evolution of Tibetan pigs and advancing our knowledge on animal adaptation to high-altitude environments.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13071
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Ma, YF,Han, XM,Huang, CP,et al. Population Genomics Analysis Revealed Origin and High-altitude Adaptation of Tibetan Pigs[J]. SCIENTIFIC REPORTS,2019,9:-.
APA	Ma, YF.,Han, XM.,Huang, CP.,Zhong, L.,Adeola, AC.,...&Zhang, YP.(2019).Population Genomics Analysis Revealed Origin and High-altitude Adaptation of Tibetan Pigs.SCIENTIFIC REPORTS,9,-.
MLA	Ma, YF,et al."Population Genomics Analysis Revealed Origin and High-altitude Adaptation of Tibetan Pigs".SCIENTIFIC REPORTS 9(2019):-.

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