The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience

	The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience
	Ardi, Z; Richter-Levin, A; Xu, L; Cao, X; Volkmer, H; Stork, O; Richter-Levin, G
	2019
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	9 页码:-
摘要	Pre-pubertal stress increases post-traumatic stress disorder (PTSD) susceptibility. We have previously demonstrated that enriched environment (EE) intervention immediately after pre-pubertal stress protects from the effects of trauma in adulthood. Here, we examined whether exposure to EE would also be beneficial if applied after exposure to trauma in adulthood. We have recently shown that exposure to juvenile stress and under-water trauma (UWT) is associated with increased expression of GABA(A) receptor subunit alpha 1 in the ventral hippocampus. However, differentiating between affected and unaffected individuals, this increased expression was confined to stress-exposed, behaviorally unaffected individuals, suggesting upregulation of alpha 1 expression as a potential mechanism of resilience. We now examined whether EE-induced resilience renders increased expression of alpha 1 in the ventral hippocampus redundant when facing a trauma later in life. Adult rats were exposed to UWT, with pre-exposure to juvenile stress, and tested in the open field and elevated plus maze paradigms four weeks later. EE exposure during juvenility prevented pre-pubertal stress-induced vulnerability, but not if performed following UWT in adulthood. Furthermore, juvenile EE exposure prevented the trauma-associated increase in alpha 1 expression levels. Our findings emphasize the importance of early interventions in order to reduce the likelihood of developing psychopathologies in adulthood.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13107
专题	科研部门_学习记忆的分子神经机制（徐林）
推荐引用方式 GB/T 7714	Ardi, Z,Richter-Levin, A,Xu, L,et al. The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience[J]. SCIENTIFIC REPORTS,2019,9:-.
APA	Ardi, Z.,Richter-Levin, A.,Xu, L.,Cao, X.,Volkmer, H.,...&Richter-Levin, G.(2019).The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience.SCIENTIFIC REPORTS,9,-.
MLA	Ardi, Z,et al."The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience".SCIENTIFIC REPORTS 9(2019):-.

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