| A neural circuit for comorbid depressive symptoms in chronic pain |
| Zhou, WJ; Jin, Y; Meng, Q; Zhu, X; Bai, TJ; Tian, YH; Mao, Y; Wang, LK; Xie, W; Zhong, H; Zhang, N; Luo, MH; Tao, WJ; Wang, HT; Li, J; Li, J; Qiu, BS; Zhou, JN; Li, XY; Xu, H; Wang, K; Zhang, XC; Liu, Y; Richter-Levin, G; Xu, L ; Zhang, Z
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| 2019
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| 发表期刊 | NATURE NEUROSCIENCE
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| ISSN | 1097-6256
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| 卷号 | 22期号:10页码:1649+ |
| 摘要 | Comorbid depressive symptoms (CDS) in chronic pain are a common health problem, but the neural circuit mechanisms underlying these symptoms remain unclear. Here we identify a novel pathway involving 5-hydroxytryptamine (5-HT) projections from the dorsal raphe nucleus (5-HTDRN) to somatostatin (SOM)-expressing and non-SOM interneurons in the central nucleus of the amygdala (CeA). The SOMCeA neurons project directly to the lateral habenula, an area known involved in depression. Inhibition of the 5-HTDRN -> SOMCeA pathway produced depression-like behavior in a male mouse model of chronic pain. Activation of this pathway using pharmacological or optogenetic approaches reduced depression-like behavior in these mice. Human functional magnetic resonance imaging data showed that compared to healthy controls, functional connectivity between the CeA-containing centromedial amygdala and the DRN was reduced in patients with CDS but not in patients in chronic pain without depression. These findings indicate that a novel 5-HTDRN -> SOMCeA -> lateral habenula pathway may mediate at least some aspects of CDS. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13108
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| 专题 | 科研部门_学习记忆的分子神经机制（徐林）
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推荐引用方式
GB/T 7714 |
Zhou, WJ,Jin, Y,Meng, Q,et al. A neural circuit for comorbid depressive symptoms in chronic pain[J]. NATURE NEUROSCIENCE,2019,22(10):1649+.
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| APA |
Zhou, WJ.,Jin, Y.,Meng, Q.,Zhu, X.,Bai, TJ.,...&Zhang, Z.(2019).A neural circuit for comorbid depressive symptoms in chronic pain.NATURE NEUROSCIENCE,22(10),1649+.
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| MLA |
Zhou, WJ,et al."A neural circuit for comorbid depressive symptoms in chronic pain".NATURE NEUROSCIENCE 22.10(2019):1649+.
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