Comparative genomic investigation of high-elevation adaptation in ectothermic snakes

	Comparative genomic investigation of high-elevation adaptation in ectothermic snakes
	Li, Jia-Tang; Gao, Yue-Dong; Xie, Liang; Deng, Cao; Shi, Peng; Guan, Meng-Long; Huang, Song; Ren, Jin-Long; Wu, Dong-Dong; Ding, Li; Huang, Zi-Yan; Nie, Hu; Humphreys, Devon P.; Hillis, David M.; Wang, Wen-Zhi; Zhang, Ya-Ping
	2018
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	115 期号:33 页码:8406-8411
摘要	Several previous genomic studies have focused on adaptation to high elevations, but these investigations have been largely limited to endotherms. Snakes of the genus Thermophis are endemic to the Tibetan plateau and therefore present an opportunity to study high-elevation adaptations in ectotherms. Here, we report the de novo assembly of the genome of a Tibetan hot-spring snake (Thermophis baileyi) and then compare its genome to the genomes of the other two species of Thermophis, as well as to the genomes of two related species of snakes that occur at lower elevations. We identify 308 putative genes that appear to be under positive selection in Thermophis. We also identified genes with shared amino acid replacements in the high-elevation hot-spring snakes compared with snakes and lizards that live at low elevations, including the genes for proteins involved in DNA damage repair (FEN1) and response to hypoxia (EPAS1). Functional assays of the FEN1 alleles reveal that the Thermophis allele is more stable under UV radiation than is the ancestral allele found in low-elevation lizards and snakes. Functional assays of EPAS1 alleles suggest that the Thermophis protein has lower transactivation activity than the low-elevation forms. Our analysis identifies some convergent genetic mechanisms in high-elevation adaptation between endotherms (based on studies of mammals) and ectotherms (based on our studies of Thermophis).
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13111
专题	科研部门_进化与功能基因组学（施鹏）遗传资源与进化国家重点实验室科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Li, Jia-Tang,Gao, Yue-Dong,Xie, Liang,et al. Comparative genomic investigation of high-elevation adaptation in ectothermic snakes[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018,115(33):8406-8411.
APA	Li, Jia-Tang.,Gao, Yue-Dong.,Xie, Liang.,Deng, Cao.,Shi, Peng.,...&Zhang, Ya-Ping.(2018).Comparative genomic investigation of high-elevation adaptation in ectothermic snakes.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(33),8406-8411.
MLA	Li, Jia-Tang,et al."Comparative genomic investigation of high-elevation adaptation in ectothermic snakes".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115.33(2018):8406-8411.

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