| The yak genome and adaptation to life at high altitude |
| Qiu, Q; Zhang, GJ; Ma, T; Qian, WB; Wang, JY; Ye, ZQ; Cao, CC; Hu, QJ; Kim, J; Larkin, DM; Auvil, L; Capitanu, B; Ma, J; Lewin, HA; Qian, XJ; Lang, YS; Zhou, R; Wang, LZ; Wang, K; Xia, JQ; Liao, SG; Pan, SK; Lu, X; Hou, HL; Wang, Y; Zang, XT; Yin, Y; Ma, H; Zhang, J; Wang, ZF; Zhang, YM; Zhang, DW; Yonezawa, T; Hasegawa, M; Zhong, Y; Liu, WB; Zhang, Y ; Huang, ZY; Zhang, SX; Long, RJ; Yang, HM; Wang, J; Lenstra, JA; Cooper, DN; Wu, Y; Wang, J; Shi, P; Wang, J; Liu, JQ
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| 2012
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| 发表期刊 | NATURE GENETICS
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| ISSN | 1061-4036
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| 卷号 | 44期号:8页码:946- |
| 摘要 | Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13133
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| 专题 | 科研部门_进化与功能基因组学（施鹏）
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推荐引用方式
GB/T 7714 |
Qiu, Q,Zhang, GJ,Ma, T,et al. The yak genome and adaptation to life at high altitude[J]. NATURE GENETICS,2012,44(8):946-.
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| APA |
Qiu, Q.,Zhang, GJ.,Ma, T.,Qian, WB.,Wang, JY.,...&Liu, JQ.(2012).The yak genome and adaptation to life at high altitude.NATURE GENETICS,44(8),946-.
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| MLA |
Qiu, Q,et al."The yak genome and adaptation to life at high altitude".NATURE GENETICS 44.8(2012):946-.
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