The twin-beginnings of COVID-19 in Asia and Europe-one prevails quickly

	The twin-beginnings of COVID-19 in Asia and Europe-one prevails quickly
	Ruan, YS; Wen, HJ; Hou, M; He, ZW; Lu, XM; Xue, YB; He, XL; Zhang, YP; Wu, CI
	2022
发表期刊	NATIONAL SCIENCE REVIEW
ISSN	2095-5138
卷号	9 期号:4
摘要	In the spread of SARS-CoV-2, there have been multiple waves of replacement between strains, each of which having a distinct set of mutations. The first wave is a group of four mutations (C241T, C3037T, C14408T and A23403G [this being the amino acid change D614G]; all designated 0 to 1 below). This DG (D614G) group, fixed at the start of the pandemic, is the foundation of all subsequent waves of strains. Curiously, the DG group is absent in early Asian samples but present (and likely common) in Europe from the beginning. European data show that the high fitness of DG1111 requires the synergistic effect of all four mutations. However, the European strains would have had no time to evolve the four DG mutations (0 to 1), had they come directly from the early Asian DG0000 strain. Very likely, the European DG1111 strain had acquired the highly adaptive DG mutations in pre-pandemic Europe and had been spreading in parallel with the Asian strains. Two recent reports further support this twin-beginning interpretation. There was a period of two-way spread between Asia and Europe but, by May 2020, the European strains had supplanted the Asian strains globally. This large-scale replacement of one set of mutations for another has since been replayed many times as COVID-19 progresses.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13141
专题	科研部门_适应性进化与进化医学（吕雪梅）昆明动物研究所科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Ruan, YS,Wen, HJ,Hou, M,et al. The twin-beginnings of COVID-19 in Asia and Europe-one prevails quickly[J]. NATIONAL SCIENCE REVIEW,2022,9(4).
APA	Ruan, YS.,Wen, HJ.,Hou, M.,He, ZW.,Lu, XM.,...&Wu, CI.(2022).The twin-beginnings of COVID-19 in Asia and Europe-one prevails quickly.NATIONAL SCIENCE REVIEW,9(4).
MLA	Ruan, YS,et al."The twin-beginnings of COVID-19 in Asia and Europe-one prevails quickly".NATIONAL SCIENCE REVIEW 9.4(2022).

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