Variation in the life history strategy underlies functional diversity of tumors

	Variation in the life history strategy underlies functional diversity of tumors
	Li, T; Liu, JL; Feng, J; Liu, ZZ; Liu, SX; Zhang, MJ; Zhang, YZ; Hou, YL; Wu, DF; Li, CY; Chen, YB; Chen, H; Lu, XM
	2021
发表期刊	NATIONAL SCIENCE REVIEW
ISSN	2095-5138
卷号	8 期号:2
摘要	Classical r- vs. K-selection theory describes the trade-offs between high reproductive output and competitiveness and guides research in evolutionary ecology. While its impact has waned in the recent past, cancer evolution may rekindle it. Herein, we impose r- or K-selection on cancer cell lines to obtain strongly proliferative r cells and highly competitive K cells to test ideas on life-history strategy evolution. RNA-seq indicates that the trade-offs are associated with distinct expression of genes involved in the cell cycle, adhesion, apoptosis, and contact inhibition. Both empirical observations and simulations based on an ecological competition model show that the trade-off between cell proliferation and competitiveness can evolve adaptively. When the r and K cells are mixed, they exhibit strikingly different spatial and temporal distributions. Due to this niche separation, the fitness of the entire tumor increases. The contrasting selective pressure may operate in a realistic ecological setting of actual tumors.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13145
专题	科研部门_适应性进化与进化医学（吕雪梅）昆明动物研究所
推荐引用方式 GB/T 7714	Li, T,Liu, JL,Feng, J,et al. Variation in the life history strategy underlies functional diversity of tumors[J]. NATIONAL SCIENCE REVIEW,2021,8(2).
APA	Li, T.,Liu, JL.,Feng, J.,Liu, ZZ.,Liu, SX.,...&Lu, XM.(2021).Variation in the life history strategy underlies functional diversity of tumors.NATIONAL SCIENCE REVIEW,8(2).
MLA	Li, T,et al."Variation in the life history strategy underlies functional diversity of tumors".NATIONAL SCIENCE REVIEW 8.2(2021).

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