Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety

	Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety
	Su, X; Li, WQ; Lv, LX; Li, XY; Yang, JF; Luo, XJ; Liu, JW
	2021
发表期刊	FRONTIERS IN GENETICS
卷号	12
摘要	Anxiety disorders are common mental disorders that often result in disability. Recently, large-scale genome-wide association studies (GWASs) have identified several novel risk variants and loci for anxiety disorders (or anxiety traits). Nevertheless, how the reported risk variants confer risk of anxiety remains unknown. To identify genes whose cis-regulated expression levels are associated with risk of anxiety traits, we conducted a transcriptome-wide association study (TWAS) by integrating genome-wide associations from a large-scale GWAS (N = 175,163) (which evaluated anxiety traits based on Generalized Anxiety Disorder 2-item scale (GAD-2) score) and brain expression quantitative trait loci (eQTL) data (from the PsychENCODE and GTEx). We identified 19 and 17 transcriptome-wide significant (TWS) genes in the PsychENCODE and GTEx, respectively. Intriguingly, 10 genes showed significant associations with anxiety in both datasets, strongly suggesting that genetic risk variants may confer risk of anxiety traits by regulating the expression of these genes. Top TWS genes included RNF123, KANSL1-AS1, GLYCTK, CRHR1, DND1P1, MAPT and ARHGAP27. Of note, 25 TWS genes were not implicated in the original GWAS. Our TWAS identified 26 risk genes whose cis-regulated expression were significantly associated with anxiety, providing important insights into the genetic component of gene expression in anxiety disorders/traits and new clues for future drug development.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13330
专题	科研部门_神经系统疾病（罗雄剑）
推荐引用方式 GB/T 7714	Su, X,Li, WQ,Lv, LX,et al. Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety[J]. FRONTIERS IN GENETICS,2021,12.
APA	Su, X.,Li, WQ.,Lv, LX.,Li, XY.,Yang, JF.,...&Liu, JW.(2021).Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety.FRONTIERS IN GENETICS,12.
MLA	Su, X,et al."Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety".FRONTIERS IN GENETICS 12(2021).

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