Whole-Genome Sequencing Reveals Lactase Persistence Adaptation in European Logs

	Whole-Genome Sequencing Reveals Lactase Persistence Adaptation in European Logs
	Liu, YH; Wang, L; Zhang, ZG; Otecko, NO; Khederzadeh, S; Dai, YQ; Liang, B; Wang, GD; Zhang, YP
	2021
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	38 期号:11 页码:4884-4890
摘要	Coexistence and cooperation between dogs and humans over thousands of years have supported convergent evolutionary processes in the two species. Previous studies found that Eurasian dogs evolved into a distinct geographic cluster. In this study, we used the genomes of 242 European dogs, 38 Southeast Asian indigenous (SEAT) dogs, and 41 gray wolves to identify adaptation of European dogs . We report 86 unique positively selected genes in European dogs, among which is LCT (lactase). LCT encodes lactase, which is fundamental for the digestion of lactose. We found that an A-to-G mutation (chr19:38,609,592) is almost fixed in Middle Eastern and European dogs. The results of two-dimensional site frequency spectrum (2D SFS) support that the mutation is under soft sweep . We inferred that the onset of positive selection of the mutation is shorter than 6,535 years and behind the well-developed dairy economy in central Europe. It increases the expression of LCT by reducing its binding with ZEB1, which would enhance dog's ability to digest milk-based diets. Our study uncovers the genetic basis of convergent evolution between humans and dogs with respect to diet, emphasizing the import of the dog as a biomedical model for studying mechanisms of the digestive system.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13392
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Liu, YH,Wang, L,Zhang, ZG,et al. Whole-Genome Sequencing Reveals Lactase Persistence Adaptation in European Logs[J]. MOLECULAR BIOLOGY AND EVOLUTION,2021,38(11):4884-4890.
APA	Liu, YH.,Wang, L.,Zhang, ZG.,Otecko, NO.,Khederzadeh, S.,...&Zhang, YP.(2021).Whole-Genome Sequencing Reveals Lactase Persistence Adaptation in European Logs.MOLECULAR BIOLOGY AND EVOLUTION,38(11),4884-4890.
MLA	Liu, YH,et al."Whole-Genome Sequencing Reveals Lactase Persistence Adaptation in European Logs".MOLECULAR BIOLOGY AND EVOLUTION 38.11(2021):4884-4890.

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