Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs

	Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs
	Cao, X; Liu, WP; Cheng, LG; Li, HJ; Wu, H; Liu, YH; Chen, C; Xiao, X; Li, M; Wang, GD; Zhang, YP
	2021
发表期刊	SCIENCE BULLETIN
ISSN	2095-9273
卷号	66 期号:2 页码:187-196
摘要	Obsessive-compulsive disorder (OCD) represents a heterogeneous collection of diseases with diverse levels of phenotypic, genetic, and etiologic variability, making it difficult to identify the underlying genetic and biological mechanisms in humans. Domestic dogs exhibit several OCD-like behaviors. Using continuous circling as a representative phenotype for OCD, we screened two independent dog breeds, the Belgian Malinois and Kunming Dog and subsequently sequenced ten circling dogs and ten unaffected dogs for each breed. Using population differentiation analyses, we identified 11 candidate genes in the extreme tail of the differentiated regions between cases and controls. These genes overlap significantly with genes identified in a genome wide association study (GWAS) of human OCD, indicating strong convergence between humans and dogs. Through gene expressional analysis and functional exploration, we found that two candidate OCD risk genes, PPP2R2B and ADAMTSL3, affected the density and morphology of dendritic spines. Therefore, changes in dendritic spine may underlie some common biological and physiological pathways shared between humans and dogs. Our study revealed an unprecedented level of convergence in OCD shared between humans and dogs, and highlighted the importance of using domestic dogs as a model species for many human diseases including OCD. (C) 2020 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13395
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Cao, X,Liu, WP,Cheng, LG,et al. Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs[J]. SCIENCE BULLETIN,2021,66(2):187-196.
APA	Cao, X.,Liu, WP.,Cheng, LG.,Li, HJ.,Wu, H.,...&Zhang, YP.(2021).Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs.SCIENCE BULLETIN,66(2),187-196.
MLA	Cao, X,et al."Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs".SCIENCE BULLETIN 66.2(2021):187-196.

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