| Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility |
| Xu, MM; Gu, LH; Lv, WY; Duan, SC; Li, LW; Du, Y; Lu, LZ; Zeng, T; Hou, ZC; Ma, ZS; Chen, W; Adeola, AC; Han, JL; Xu, TS; Dong, Y; Zhang, YP ; Peng, MS
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| 2022
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| 发表期刊 | GENOMICS
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| ISSN | 0888-7543
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| 卷号 | 114期号:6 |
| 摘要 | The Muscovy duck (Cairina moschata) is an economically important poultry species, which is susceptible to fatty liver. Thus, the Muscovy duck may serve as an excellent candidate animal model of non-alcoholic fatty liver disease. However, the mechanisms underlying fatty liver development in this species are poorly understood. In this study, we report a chromosome-level genome assembly of the Muscovy duck, with a contig N50 of 11.8 Mb and scaffold N50 of 83.16 Mb. The susceptibility of Muscovy duck to fatty liver was mainly attributed to weak lipid catabolism capabilities (fatty acid beta-oxidation and lipolysis). Furthermore, conserved noncoding elements (CNEs) showing accelerated evolution contributed to fatty liver formation by down-regulating the expression of genes involved in hepatic lipid catabolism. We propose that the susceptibility of Muscovy duck to fatty liver is an evolutionary by-product. In conclusion, this study revealed the potential mechanisms underlying the susceptibility of Muscovy duck to fatty liver. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13400
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| 专题 | 科研部门_分子进化与基因组多样性（张亚平）
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推荐引用方式
GB/T 7714 |
Xu, MM,Gu, LH,Lv, WY,et al. Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility[J]. GENOMICS,2022,114(6).
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| APA |
Xu, MM.,Gu, LH.,Lv, WY.,Duan, SC.,Li, LW.,...&Peng, MS.(2022).Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility.GENOMICS,114(6).
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| MLA |
Xu, MM,et al."Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility".GENOMICS 114.6(2022).
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