Convergent genomic signatures of high-altitude adaptation among domestic mammals

	Convergent genomic signatures of high-altitude adaptation among domestic mammals
	Wu, DD; Yang, CP; Wang, MS; Dong, KZ; Yan, DW; Hao, ZQ; Fan, SQ; Chu, SZ; Shen, QS; Jiang, LP; Li, Y; Zeng, L; Liu, HQ; Xie, HB; Ma, YF; Kong, XY; Yang, SL; Dong, XX; Esmailizadeh, A; Irwin, DM; Xiao, X; Li, M; Dong, Y; Wang, W; Shi, P; Li, HP; Ma, YH; Gou, X; Chen, YB; Zhang, YP
	2020
发表期刊	NATIONAL SCIENCE REVIEW
ISSN	2095-5138
卷号	7 期号:6 页码:952-963
摘要	Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13404
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Wu, DD,Yang, CP,Wang, MS,et al. Convergent genomic signatures of high-altitude adaptation among domestic mammals[J]. NATIONAL SCIENCE REVIEW,2020,7(6):952-963.
APA	Wu, DD.,Yang, CP.,Wang, MS.,Dong, KZ.,Yan, DW.,...&Zhang, YP.(2020).Convergent genomic signatures of high-altitude adaptation among domestic mammals.NATIONAL SCIENCE REVIEW,7(6),952-963.
MLA	Wu, DD,et al."Convergent genomic signatures of high-altitude adaptation among domestic mammals".NATIONAL SCIENCE REVIEW 7.6(2020):952-963.

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