Genome-wide investigations reveal the population structure and selection signatures of Nigerian cattle adaptation in the sub-Saharan tropics

	Genome-wide investigations reveal the population structure and selection signatures of Nigerian cattle adaptation in the sub-Saharan tropics
	Mauki, DH; Tijjani, A; Ma, C; Ng'ang'a, SI; Mark, AI; Sanke, OJ; Abdussamad, AM; Olaogun, SC; Ibrahim, J; Dawuda, PM; Mangbon, GF; Kazwala, RR; Gwakisa, PS; Yin, TT; Li, Y; Peng, MS; Adeola, AC; Zhang, YP
	2022
发表期刊	BMC GENOMICS
ISSN	1471-2164
卷号	23 期号:1
摘要	Background Cattle are considered to be the most desirable livestock by small scale farmers. In Africa, although comprehensive genomic studies have been carried out on cattle, the genetic variations in indigenous cattle from Nigeria have not been fully explored. In this study, genome-wide analysis based on genotyping-by-sequencing (GBS) of 193 Nigerian cattle was used to reveal new insights on the history of West African cattle and their adaptation to the tropical African environment, particularly in sub-Saharan region. Results The GBS data were evaluated against whole-genome sequencing (WGS) data and high rate of variant concordance between the two platforms was evident with high correlated genetic distance matrices genotyped by both methods suggestive of the reliability of GBS applicability in population genetics. The genetic structure of Nigerian cattle was observed to be homogenous and unique from other African cattle populations. Selection analysis for the genomic regions harboring imprints of adaptation revealed genes associated with immune responses, growth and reproduction, efficiency of feeds utilization, and heat tolerance. Our findings depict potential convergent adaptation between African cattle, dogs and humans with adaptive genes SPRY2 and ITGB1BP1 possibly involved in common physiological activities. Conclusion The study presents unique genetic patterns of Nigerian cattle which provide new insights on the history of cattle in West Africa based on their population structure and the possibility of parallel adaptation between African cattle, dogs and humans in Africa which require further investigations.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13409
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Mauki, DH,Tijjani, A,Ma, C,et al. Genome-wide investigations reveal the population structure and selection signatures of Nigerian cattle adaptation in the sub-Saharan tropics[J]. BMC GENOMICS,2022,23(1).
APA	Mauki, DH.,Tijjani, A.,Ma, C.,Ng'ang'a, SI.,Mark, AI.,...&Zhang, YP.(2022).Genome-wide investigations reveal the population structure and selection signatures of Nigerian cattle adaptation in the sub-Saharan tropics.BMC GENOMICS,23(1).
MLA	Mauki, DH,et al."Genome-wide investigations reveal the population structure and selection signatures of Nigerian cattle adaptation in the sub-Saharan tropics".BMC GENOMICS 23.1(2022).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023031542.pdf（6648KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文